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Small-animal tomography with a liquid-metal-jet x-ray source
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.ORCID iD: 0000-0002-9487-669X
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.ORCID iD: 0000-0001-7637-1850
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.
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2012 (English)In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, SPIE - International Society for Optical Engineering, 2012, Vol. 8313, p. 83130N-Conference paper, Published paper (Refereed)
Abstract [en]

X-ray tomography of small animals is an important tool for medical research. For high-resolution x-ray imaging of few-cm-thick samples such as, e.g., mice, high-brightness x-ray sources with energies in the few-10-keV range are required. In this paper we perform the first small-animal imaging and tomography experiments using liquid-metal-jet-anode x-ray sources. This type of source shows promise to increase the brightness of microfocus x-ray systems, but present sources are typically optimized for an energy of 9 keV. Here we describe the details of a high-brightness 24-keV electron-impact laboratory microfocus x-ray source based on continuous operation of a heated liquid-In/Ga-jet anode. The source normally operates with 40 W of electron-beam power focused onto the metal jet, producing a 7×7 μm 2 FWHM x-ray spot. The peak spectral brightness is 4 × 10 9 photons/( s × mm 2 × mrad 2 × 0.1%BW) at the 24.2 keV In K α line. We use the new In/Ga source and an existing Ga/In/Sn source for high-resolution imaging and tomography of mice.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2012. Vol. 8313, p. 83130N-
Series
Progress in Biomedical Optics and Imaging, ISSN 1605-7422 ; 8313
Keywords [en]
liquid-metal-jet-anode, mouse, Small-animal imaging, tomography, x-ray
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-98179DOI: 10.1117/12.910777ISI: 000304768000021Scopus ID: 2-s2.0-84860385685ISBN: 978-081948962-3 (print)OAI: oai:DiVA.org:kth-98179DiVA, id: diva2:536101
Conference
Medical Imaging 2012: Physics of Medical Imaging;San Diego, CA;5 February 2012 through 8 February 2012
Note
QC 20120621Available from: 2012-06-21 Created: 2012-06-20 Last updated: 2014-01-14Bibliographically approved

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Larsson, Daniel H.Lundström, UlfBurvall, AnnaHertz, Hans M.

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