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X-ray phase contrast angiography using CO 2 as contrast agent
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.ORCID iD: 0000-0001-7637-1850
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.ORCID iD: 0000-0002-9487-669X
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.
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2012 (English)In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, SPIE - International Society for Optical Engineering, 2012, Vol. 8313, 83135J- p.Conference paper, Published paper (Refereed)
Abstract [en]

We investigate the possibility of using x-ray in-line phase-contrast imaging with gaseous carbon dioxide as contrast agent to visualize small blood vessels. These are difficult to image at reasonable radiation doses using the absorption of conventional iodinated contrast agents. In-line phase contrast is a method for retrieving information on the electron density of the sample as well as the absorption, by moving the detector away from the sample to let phase variations in the transmitted x-rays develop into intensity variations at the detector. Blood vessels are normally difficult to observe in phase contrast even with iodinated contrast agents as the density difference compared to most tissues is small. Carbon dioxide is a clinically accepted x-ray contrast agent. The gas is injected into the blood stream of patients to temporarily displace the blood in a region and thereby reduce the x-ray absorption in the blood vessels. This gives a large density difference which is ideal for phase-contrast imaging. We demonstrate the possibilities of the method by imaging the arterial system of a rat kidney injected with carbon dioxide. Vessels down to 23 ÎŒm in diameter are shown. The method shows potential for live small-animal imaging.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2012. Vol. 8313, 83135J- p.
Series
Progress in Biomedical Optics and Imaging, ISSN 1605-7422 ; 8313
Keyword [en]
angiography, CO 2, phase contrast, x-ray, Arterial systems, Blood streams, Contrast agent, Density difference, In-line, In-line phase contrast, In-phase, Intensity variations, Iodinated contrast agents, Phase contrasts, Phase variation, Phase-contrast imaging, Rat kidneys, Small animal imaging, X ray phase contrast, Blood vessels, Medical imaging, Tissue, X rays, Carbon dioxide
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-98180DOI: 10.1117/12.911408ISI: 000304768000190Scopus ID: 2-s2.0-84860357542ISBN: 978-081948962-3 (print)OAI: oai:DiVA.org:kth-98180DiVA: diva2:536228
Conference
Medical Imaging 2012: Physics of Medical Imaging;San Diego, CA;5 February 2012 through 8 February 2012
Note
QC 20120621Available from: 2012-06-21 Created: 2012-06-20 Last updated: 2014-01-14Bibliographically approved

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Lundström, UlfLarsson, Daniel H.Burvall, AnnaHertz, Hans M.

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