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Separation of Chiral Particles in Micro- or Nanofluidic Channels
KTH, Centres, Nordic Institute for Theoretical Physics NORDITA.
2012 (English)In: Physical Review Letters, ISSN 0031-9007, Vol. 108, no 21, 214504- p.Article in journal (Refereed) Published
Abstract [en]

We propose a method to separate enantiomers in microfluidic or nanofluidic channels. It requires flow profiles that break chiral symmetry and have regions with high local shear. Such profiles can be generated in channels confined by walls with different hydrodynamic boundary conditions (e.g., slip lengths). Because of a nonlinear hydrodynamic effect, particles with different chirality migrate at different speeds and can be separated. The mechanism is demonstrated by computer simulations. We investigate the influence of thermal fluctuations (i.e., the Peclet number) and show that the effect disappears in the linear response regime. The details of the microscopic flow are important and determine which volume forces are necessary to achieve separation.

Place, publisher, year, edition, pages
2012. Vol. 108, no 21, 214504- p.
Keyword [en]
Chirality, Computer simulation, Enantiomers, Fluid dynamics, Nanofluidics
National Category
Physical Sciences
URN: urn:nbn:se:kth:diva-98332DOI: 10.1103/PhysRevLett.108.214504ISI: 000304404700013ScopusID: 2-s2.0-84861581402OAI: diva2:536962

QC 20120625

Available from: 2012-06-25 Created: 2012-06-25 Last updated: 2013-08-28Bibliographically approved

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Eichhorn, Ralf
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