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'Green'-synthesized near-infrared PbS quantum dots with silica-PEG dual-layer coating: ultrastable and biocompatible optical probes for in vivo animal imaging
KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, School of Electrical Engineering (EES), Electromagnetic Engineering.ORCID iD: 0000-0002-3401-1125
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2012 (English)In: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 23, no 24, 245701- p.Article in journal (Refereed) Published
Abstract [en]

In this paper, PbS semiconductor quantum dots (QDs) with near-infrared (NIR) photoluminescence were synthesized in oleic acid and paraffin liquid mixture by using an easily handled and 'green' approach. Surface functionalization of the QDs was accomplished with a silica and polyethylene glycol (PEG) phospholipid dual-layer coating and the excellent chemical stability of the nanoparticles is demonstrated. We then successfully applied the ultrastable PbS QDs to in vivo sentinel lymph node (SLN) mapping of mice. Histological analyses were also carried out to ensure that the intravenously injected nanoparticles did not produce any toxicity to the organism of mice. These experimental results suggested that our ultrastable NIR PbS QDs can serve as biocompatible and efficient probes for in vivo optical bioimaging and has great potentials for disease diagnosis and clinical therapies in the future.

Place, publisher, year, edition, pages
2012. Vol. 23, no 24, 245701- p.
National Category
Nano Technology Materials Engineering
Identifiers
URN: urn:nbn:se:kth:diva-98919DOI: 10.1088/0957-4484/23/24/245701ISI: 000305160500009Scopus ID: 2-s2.0-84861584390OAI: oai:DiVA.org:kth-98919DiVA: diva2:540914
Note

QC 20120712

Available from: 2012-07-12 Created: 2012-07-05 Last updated: 2017-06-13Bibliographically approved

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He, Sailing

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Wang, DanCai, FuhongHe, Sailing
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