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Improvement in cell capture throughput using parallel bioactivated microfluidic channels
KTH, School of Biotechnology (BIO), Biochemistry.
KTH, School of Biotechnology (BIO), Biochemistry.
2012 (English)In: Biomedical microdevices (Print), ISSN 1387-2176, E-ISSN 1572-8781, Vol. 14, no 4, 625-629 p.Article in journal (Refereed) Published
Abstract [en]

Optimization of targeted cell capture with microfluidic devices continues to be a challenge. On the one hand, microfluidics allow working with microliter volumes of liquids, whereas various applications in the real world require detection of target analyte in large volumes, such as capture of rare cell types in several ml of blood. This contrast of volumes (microliter vs. ml) has prevented the emergence of microfluidic cell capture sensors in the clinical setting. Here, we study the improvement in cell capture and throughput achieved using parallel bioactivated microfluidic channels. The device consists of channels in parallel with each other tied to a single channel. We discuss fabrication and testing of our devices, and show the ability for an improvement in throughput detection of target cells.

Place, publisher, year, edition, pages
2012. Vol. 14, no 4, 625-629 p.
Keyword [en]
Microfluidics, Cell capture, Pathogen detection
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-99393DOI: 10.1007/s10544-012-9643-xISI: 000305951500001Scopus ID: 2-s2.0-84865416226OAI: oai:DiVA.org:kth-99393DiVA: diva2:542279
Note
QC 20120731Available from: 2012-07-31 Created: 2012-07-30 Last updated: 2017-12-07Bibliographically approved

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