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Hemolytic properties of synthetic nano- and porous silica particles: The effect of surface properties and the protection by the plasma corona
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Surface and Corrosion Science.ORCID iD: 0000-0003-2145-3650
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Surface and Corrosion Science.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Surface and Corrosion Science.ORCID iD: 0000-0003-2206-0082
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2012 (English)In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 8, no 9, 3478-3490 p.Article in journal (Refereed) Published
Abstract [en]

Novel silica materials incorporating nanotechnology are promising materials for biomedical applications, but their novel properties may also bring unforeseen behavior in biological systems. Micro-size silica is well documented to induce hemolysis, but little is known about the hemolytic activities of nanostructured silica materials. In this study, the hemolytic properties of synthetic amorphous silica nanoparticles with primary sizes of 7-14 nm (hydrophilic vs. hydrophobic), 5-15 nm, 20 nm and 50 nm, and model meso/macroporous silica particles with pore diameters of 40 nm and 170 nm are investigated. A crystalline silica sample (0.5-10 ÎŒm) is included for benchmarking purposes. Special emphasis is given to investigations of how the temperature and solution complexity (solvent, plasma), as well as the physicochemical properties (such as size, surface charge, hydrophobicity and other surface properties), link to the hemolytic activities of these particles. Results suggests the potential importance of small size and large external surface area, as well as surface charge/structure, in the hemolysis of silica particles. Furthermore, a significant correlation is observed between the hemolytic profile of red blood cells and the cytotoxicity profile of human promyelocytic leukemia cells (HL-60) induced by nano- and porous silica particles, suggesting a potential universal mechanism of action. Importantly, the results generated suggest that the protective effect of plasma towards silica nanoparticle-induced hemolysis as well as cytotoxicity is primarily due to the protein/lipid layer shielding the silica particle surface. These results will assist the rational design of hemocompatible silica particles for biomedical applications.

Place, publisher, year, edition, pages
2012. Vol. 8, no 9, 3478-3490 p.
Keyword [en]
Cytotoxicity, Hemolysis, Plasma protection, Surface charge, Synthetic silica nanoparticles
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Other Chemistry Topics
Identifiers
URN: urn:nbn:se:kth:diva-101341DOI: 10.1016/j.actbio.2012.04.024ISI: 000307625900030Scopus ID: 2-s2.0-84864401190OAI: oai:DiVA.org:kth-101341DiVA: diva2:547932
Funder
Swedish Research CouncilKnut and Alice Wallenberg Foundation
Note

QC 20120829

Available from: 2012-08-29 Created: 2012-08-27 Last updated: 2017-12-07Bibliographically approved

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Hedberg, YolandaOdnevall Wallinder, Inger

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