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Modulation of Cell Adhesion Complexes by Surface Protein Patterns
KTH, School of Engineering Sciences (SCI), Applied Physics, Nanostructure Physics.
2009 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, Vol. 1, no 3, 543-548 p.Article in journal (Refereed) Published
Abstract [en]

Cell adhesion is an important process in several biological phenomena. To investigate the formation and organization of focal adhesions, we developed a patterning approach based on electron beam lithography. Nanodots (radius <1230 nm) and nanorings (inner radius <320 nm) of fibronectin (FN) were patterned on a K-Casein background. Intracellular vinculin immunofluorescence mirrored the FN nanopatterns. Atomic force microscopy showed that FN nanodots and nanorings organize the immediate cytoskeleton into straight fibrils and diverging fibril bundles, respectively. Our results suggest that a minimum of similar to 40 FN molecules is required for a cell to form a Focal adhesion.

Place, publisher, year, edition, pages
2009. Vol. 1, no 3, 543-548 p.
Keyword [en]
cell adhesion, fibronectin, atomic force microscopy, electron beam lithography
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Other Physics Topics
URN: urn:nbn:se:kth:diva-101653DOI: 10.1021/am800264hISI: 000267535900004ScopusID: 2-s2.0-76749105401OAI: diva2:548446

QC 20120830

Available from: 2012-08-30 Created: 2012-08-30 Last updated: 2012-08-30Bibliographically approved

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Pesen, Devrim
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