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PLGA-PEG multifunctional nanoparticles for simultaneous drug delivery and imaging by MRI and fluorescence microscopy
KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.
KTH, School of Information and Communication Technology (ICT), Material Physics, Functional Materials, FNM.ORCID iD: 0000-0001-5678-5298
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2012 (English)In: Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012, 2012, 4-7 p.Conference paper, Published paper (Refereed)
Abstract [en]

This work deals with the synthesis of multifunctional nanoparticles based on biocompatible di-block copolymer (PLGA-PEG) via an emulsion-evaporation method. To enable their visualization, these nanoparticles can be loaded with iron oxide nanoparticles for Magnetic Resonance Imaging (MRI) and/or quantum dots for fluorescent microscopy. A therapeutic agent, Indomethacin, can also be loaded and released. The influence of synthesis parameters on nanoparticle size (in the range 70-150 nm) has been controlled to achieve specific cellular interactions avoiding possible immuno-response. These multifunctional nanoparticles possess excellent photoemission properties for fluorescent microscopy and enhanced contrast efficiency for T 2 MRI imaging compared to available agents used today. In-vitro experiments confirm the low cytotoxicity of such nanoparticles and their excellent visualization properties by MRI and fluorescence microscopy in cells and biological tissues.

Place, publisher, year, edition, pages
2012. 4-7 p.
Keyword [en]
Drug delivery, MRI, Multifunctional nanoparticle, PLGA-PEG, Quantum dots
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-101346Scopus ID: 2-s2.0-84865023832ISBN: 978-146656276-9 (print)OAI: oai:DiVA.org:kth-101346DiVA: diva2:549162
Conference
Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012; Santa Clara, CA;18 June 2012 through 21 June 2012
Note

QC 20120903

Available from: 2012-09-03 Created: 2012-08-27 Last updated: 2012-09-03Bibliographically approved

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Authority records BETA

Toprak, Muhammet S.

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Fornara, AndreaChiavarino, AnnalisaQin, JianToprak, Muhammet S.Muhammed, Mamoun
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