PLGA-PEG multifunctional nanoparticles for simultaneous drug delivery and imaging by MRI and fluorescence microscopy
2012 (English)In: Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012, 2012, 4-7 p.Conference paper (Refereed)
This work deals with the synthesis of multifunctional nanoparticles based on biocompatible di-block copolymer (PLGA-PEG) via an emulsion-evaporation method. To enable their visualization, these nanoparticles can be loaded with iron oxide nanoparticles for Magnetic Resonance Imaging (MRI) and/or quantum dots for fluorescent microscopy. A therapeutic agent, Indomethacin, can also be loaded and released. The influence of synthesis parameters on nanoparticle size (in the range 70-150 nm) has been controlled to achieve specific cellular interactions avoiding possible immuno-response. These multifunctional nanoparticles possess excellent photoemission properties for fluorescent microscopy and enhanced contrast efficiency for T 2 MRI imaging compared to available agents used today. In-vitro experiments confirm the low cytotoxicity of such nanoparticles and their excellent visualization properties by MRI and fluorescence microscopy in cells and biological tissues.
Place, publisher, year, edition, pages
2012. 4-7 p.
Drug delivery, MRI, Multifunctional nanoparticle, PLGA-PEG, Quantum dots
Engineering and Technology
IdentifiersURN: urn:nbn:se:kth:diva-101346ScopusID: 2-s2.0-84865023832ISBN: 978-146656276-9OAI: oai:DiVA.org:kth-101346DiVA: diva2:549162
Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012; Santa Clara, CA;18 June 2012 through 21 June 2012
QC 201209032012-09-032012-08-272012-09-03Bibliographically approved