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Tuning a synthetic in vitro oscillator using control-theoretic tools
KTH, School of Electrical Engineering (EES), Automatic Control.
2010 (English)In: Proceedings of the IEEE Conference on Decision and Control, NEW YORK: IEEE , 2010, 2554-2559 p.Conference paper (Other academic)
Abstract [en]

This paper demonstrates the effectiveness of simple control-theoretic tools in generating simulation-guided experiments on a synthetic in vitro oscillator. A theoretical analysis of the behavior of such system is motivated by high cost, time consuming experiments, together with the excessive number of tuning parameters. A simplified model of the synthetic oscillator is chosen to capture only its essential features. The model is analyzed using the small gain theorem and the theory of describing functions. Such analysis reveals what are the parameters that primarily determine when the system can admit stable oscillations. Experimental verification of the theoretical and numerical findings is carried out and confirms the predicted results regarding the role of production and degradation rates.

Place, publisher, year, edition, pages
NEW YORK: IEEE , 2010. 2554-2559 p.
National Category
Control Engineering
URN: urn:nbn:se:kth:diva-101638DOI: 10.1109/CDC.2010.5718111ISI: 000295049103001ScopusID: 2-s2.0-79953127501ISBN: 978-1-4244-7746-3OAI: diva2:549483
2010 49th IEEE Conference on Decision and Control, CDC 2010;Atlanta, GA

CQ 20120904

Available from: 2012-09-04 Created: 2012-08-30 Last updated: 2012-09-04Bibliographically approved

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Sturk, Christopher
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ReferencesLink to record
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