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DLRS: gene tree evolution in light of a species tree
Dept. of Numerical Analysis and Computer Science, Stockholm University.
Karolinska Institutet.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB. (Swedish E-Science Research Centre, Sweden)
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB. KTH, Centres, Science for Life Laboratory, SciLifeLab.
2012 (English)In: Bioinformatics, ISSN 1367-4803, E-ISSN 1367-4811, Vol. 28, no 22, 2994-2995 p.Article in journal (Refereed) Published
Abstract [en]

PrIME-DLRS (or colloquially: 'Delirious') is a phylogenetic software tool to simultaneously infer and reconcile a gene tree given a species tree. It accounts for duplication and loss events, a relaxed molecular clock and is intended for the study of homologous gene families, for example in a comparative genomics setting involving multiple species. PrIME-DLRS uses a Bayesian MCMC framework, where the input is a known species tree with divergence times and a multiple sequence alignment, and the output is a posterior distribution over gene trees and model parameters.

Place, publisher, year, edition, pages
Oxford University Press, 2012. Vol. 28, no 22, 2994-2995 p.
Keyword [en]
Dna-Sequences
National Category
Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:kth:diva-102826DOI: 10.1093/bioinformatics/bts548ISI: 000311303500022PubMedID: 22982573Scopus ID: 2-s2.0-84869442139OAI: oai:DiVA.org:kth-102826DiVA: diva2:556827
Funder
Swedish Research Council, 2010-4757Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceSwedish e‐Science Research Center
Note

QC 20120926

Available from: 2012-09-26 Created: 2012-09-26 Last updated: 2017-12-07Bibliographically approved

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