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Remodeling of Intramural Thrombus and Collagen in an Ang-II Infusion ApoE-/- Model of Dissecting Aortic Aneurysms
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
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2012 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 130, no 3, E139-E146 p.Article in journal (Refereed) Published
Abstract [en]

Fibrillar collagen endows the normal aortic wall with significant stiffness and strength and similarly plays important roles in many disease processes. For example, because of the marked loss of elastic fibers and functional smooth cells in aortic aneurysms, collagen plays a particularly important role in controlling the dilatation of these lesions and governing their rupture potential. Recent findings suggest further that collagen remodeling may also be fundamental to the intramural healing of arterial or aneurysmal dissections. To explore this possibility further, we identified and correlated regions of intramural thrombus and newly synthesized fibrillar collagen in a well-established mouse model of dissecting aortic aneurysms. Our findings suggest that intramural thrombus that is isolated from free-flowing blood creates a permissive environment for the synthesis of fibrillar collagen that, albeit initially less dense and organized, could protect that region of the dissected wall from subsequent expansion of the dissection or rupture. Moreover, alpha-smooth muscle actin positive cells appeared to be responsible for the newly produced collagen, which co-localized with significant production of glycosaminoglycans.

Place, publisher, year, edition, pages
2012. Vol. 130, no 3, E139-E146 p.
Keyword [en]
Thrombosis, Glycosaminoglycans, Collagen remodeling, Rupture, Thoracic aneurysm
National Category
Hematology
Identifiers
URN: urn:nbn:se:kth:diva-103150DOI: 10.1016/j.thromres.2012.04.009ISI: 000308078800022Scopus ID: 2-s2.0-84865247980OAI: oai:DiVA.org:kth-103150DiVA: diva2:559382
Funder
EU, FP7, Seventh Framework Programme, 248782
Note

QC 20121009

Available from: 2012-10-09 Created: 2012-10-04 Last updated: 2017-12-07Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
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  • Other locale
More languages
Output format
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