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Numerical modeling of Atomic Force Microscopy (AFM) towards estimation of material parameters from fibroblast cells.
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
2011 (English)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

It has a long been known that many, if not all, diseases are associated with changes in the mechanical

properties of cells. Although these changes in tissue mechanics have been believed to be a

conseguence of the disease, recent data show that alterations of these mechanical properties have

potent eect to many cellular functions. Thus, there is no reason to believe that altered cellular

mechanics could be a cause of the disease, rather than its consequence. A complete understanding

of cell mechanics and how the latter one depends on the presence of a disease is therefore necessary

in order to develop methods of early diagnosis.

In this master thesis we report the preliminary results of cell mechanical response of broblasts

obtained simulating AFM (Atomic Force Microscopy) with COMSOL 4.1. Specically, we tried to

nd out what is the relationship that coexists between the reaction force of a broblast when urged

by this type of technique. A subsequent process of reverse engineering led to a simply analytical

model for the quantication of the mechanical properties of this type of cell.

The second part of this work aims to improve the understading of the mechanotrasduction

mechanism of cells. The second model, indeed, reports the results of soft concact and adhesion of

a broblast with a polyacrylamide substrate.

Finally, we built up a numerical model that combines the assumptios of the rst and the second one.

Place, publisher, year, edition, pages
2011. , 44 p.
National Category
Applied Mechanics
URN: urn:nbn:se:kth:diva-103880OAI: diva2:562186
Subject / course
Solid Mechanics
Available from: 2013-10-30 Created: 2012-10-23 Last updated: 2013-10-30Bibliographically approved

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GiulioFerrazzi(2869 kB)471 downloads
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