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Philips Microdose Mammography - the Technology and Physics Behind the First FDA Approved Photon Counting X-Ray Imaging System
KTH, School of Engineering Sciences (SCI), Physics, Physics of Medical Imaging.ORCID iD: 0000-0002-3039-9791
2012 (English)In: Medical physics (Lancaster), ISSN 0094-2405, Vol. 39, no 6, 4017-4017 p.Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Purpose: To validate the use of 4D‐Computed Tomography (4D‐CT) for pre‐treatment evaluation of fractional regional ventilation in patients with lung cancer by benchmarking its performance against scintigraphy V/Q imaging, the current gold‐standard. The second aim is to further corroborate the results of 4D‐CT estimation of lung aeration against the results of Pulmonary Function Testing. Methods: Scintigraphy V/Q and 4D‐CT studies were acquired in four lung cancer patients prior to treatment with radiation therapy. PFTs were acquired in 3 out of the 4 patients. 4D‐CT images were used to create 3D fractional regional ventilation maps by applying a ‘mass correction’ and subtracting the spatially matched end‐exhale and end‐inhale images. Ventilation maps were then collapsed in the anterior‐posterior dimension to create a coronal 2D projection image consistent with the scintigraphy V/Q images. The left and right lung fields were isolated on the projection image and divided into 3 sections of equal height. Summation of the signal intensity in each of the sections was carried out on the maps analogous to the analysis performed on V/Q scans and statistically compared using the Kendall's tau rank correlation. Results: The non‐parametric Kendall's tau estimate ranged between 0.87–0.95 for N=4, with corresponding p‐values ranging between 0.005–0.0002. Mean functional residual capacities (FRC) from the PFTs (N=3) versus calculated FRCs was 2.7 +/− 0.6 L and 2.4 +/− 0.7 L, and the null hypothesis could not be rejected (p = 0.61). The mean fractional regional ventilation versus the ratio of tidal‐volume/FRC was 0.24 +/− 0.11 and 0.22 +/− 0.08, and the null hypothesis could not be rejected (p=0.73). Conclusions: There was a strong correlation between 4D‐CT and scintigraphy V/Q. The similarity between the calculated and measured FRCs further validates the utility of 4D‐CT and supports its use in evaluating lung ventilation in patients with pulmonary neoplasms.

Place, publisher, year, edition, pages
2012. Vol. 39, no 6, 4017-4017 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-104271ISI: 000308905805841Scopus ID: 2-s2.0-85024811016OAI: oai:DiVA.org:kth-104271DiVA: diva2:565122
Conference
54th Annual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine (AAPM), JUL 29-AUG 02, 2012, Charlotte, NC
Note

QC 20121106

Available from: 2012-11-06 Created: 2012-10-31 Last updated: 2017-08-14Bibliographically approved

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