Sequential interpenetrating poly(ethylene glycol) hydrogels prepared by UV-initiated thiol–ene coupling chemistry
2013 (English)In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 51, no 2, 363-371 p.Article in journal (Refereed) Published
Poly(ethylene glycol) (PEG)-diallyls, ranging from 2 to 8 kDa, were successfully reacted with a trifunctional thiol crosslinker via thiol–ene coupling reaction to construct four different primary PEG hydrogels. These systems were used as scaffolds for the preparation of a library of sequential interpenetrating networks (SeqIPNs). The solid content of the secondary networks varied between 21 and 34% and was dependent on the length of the absorbing PEGs. The gel fractions for the IPNs were above 85%. Additionally, the lowest degree of swelling was found for the IPN based on 2-kDa PEG (315%), whereas the 8-kDa PEG IPN exhibited a value of 810%. The SeqIPN strategy facilitated hydrogel systems that cover a larger domain of tensile modulus (192–889 kPa) when compared with single hydrogel networks (175–555 kPa).
Place, publisher, year, edition, pages
2013. Vol. 51, no 2, 363-371 p.
hydrogels, modulus, networks, polyethers, poly(ethylene glycol), swelling degree, thiol–ene click chemistry, UV curing
IdentifiersURN: urn:nbn:se:kth:diva-105557DOI: 10.1002/pola.26393ISI: 000312448800016ScopusID: 2-s2.0-84870981886OAI: oai:DiVA.org:kth-105557DiVA: diva2:571463
FunderSwedish Research Council, 2010-453
QC 201211222012-11-222012-11-222013-01-21Bibliographically approved