Efficient kinetic resolution of amino acids catalyzed by lipase AS 'Amano' via cleavage of an amide bond
2012 (English)In: Tetrahedron: asymmetry, ISSN 0957-4166, E-ISSN 1362-511X, Vol. 23, no 18-19, 1338-1342 p.Article in journal (Refereed) Published
Herein the efficient kinetic resolution of non-natural alpha-amino acids catalyzed by lipase AS 'Amano' via cleaving the amide bond is reported. The starting materials were the corresponding amino acid amides and the amino acids were generated with ees of up to 99% with E values of >600. These results indicated that the lipase AS 'Amano' could be a powerful amide hydrolase for the kinetic resolution of amino acid starting from the corresponding amino acid amides.
Place, publisher, year, edition, pages
2012. Vol. 23, no 18-19, 1338-1342 p.
alpha amino acid, amide, triacylglycerol lipase, article, catalysis, chemical reaction kinetics, concentration (parameters), enantioselectivity, hydrogen bond, pH, priority journal
Biological Sciences Other Chemistry Topics
IdentifiersURN: urn:nbn:se:kth:diva-106949DOI: 10.1016/j.tetasy.2012.08.017ISI: 000310863400003ScopusID: 2-s2.0-84867778214OAI: oai:DiVA.org:kth-106949DiVA: diva2:574288
QC 201212052012-12-052012-12-052012-12-21Bibliographically approved