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MHC variability supports dog domestication from a large number of wolves: high diversity in Asia
KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
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2013 (English)In: Heredity, ISSN 0018-067X, E-ISSN 1365-2540, Vol. 110, no 1, 80-85 p.Article in journal (Refereed) Published
Abstract [en]

The process of dog domestication is still somewhat unresolved. Earlier studies indicate that domestic dogs from all over the world have a common origin in Asia. So far, major histocompatibility complex (MHC) diversity has not been studied in detail in Asian dogs, although high levels of genetic diversity are expected at the domestication locality. We sequenced the second exon of the canine MHC gene DLA-DRB1 from 128 Asian dogs and compared our data with a previously published large data set of MHC alleles, mostly from European dogs. Our results show that Asian dogs have a higher MHC diversity than European dogs. We also estimated that there is only a small probability that new alleles have arisen by mutation since domestication. Based on the assumption that all of the currently known 102 DLA-DRB1 alleles come from the founding wolf population, we simulated the number of founding wolf individuals. Our simulations indicate an effective population size of at least 500 founding wolves, suggesting that the founding wolf population was large or that backcrossing has taken place.

Place, publisher, year, edition, pages
2013. Vol. 110, no 1, 80-85 p.
Keyword [en]
Asia, MHC, DLA-DRB1, dog, domestication, founding population
National Category
Biological Sciences
URN: urn:nbn:se:kth:diva-108089DOI: 10.1038/hdy.2012.67ISI: 000312496900011ScopusID: 2-s2.0-84871089764OAI: diva2:578928
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceKnut and Alice Wallenberg Foundation

QC 20140613

Available from: 2012-12-19 Created: 2012-12-19 Last updated: 2014-06-26Bibliographically approved

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Hagström, ErikSavolainen, Peter
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Gene TechnologyScience for Life Laboratory, SciLifeLab
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