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pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers
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2013 (English)In: Soft Matter, ISSN 1744-683X, E-ISSN 1744-6848, Vol. 9, no 1, 82-89 p.Article in journal (Refereed) Published
Abstract [en]

Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hydrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.

Place, publisher, year, edition, pages
2013. Vol. 9, no 1, 82-89 p.
Keyword [en]
Drug-Delivery, Hydrogels, Gels, Polymer, Therapeutics, Proteins, Biology, Driven, Cancer
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-109600DOI: 10.1039/c2sm26996aISI: 000311964200009Scopus ID: 2-s2.0-84870483489OAI: oai:DiVA.org:kth-109600DiVA: diva2:584436
Funder
Swedish Research Council, 2009-3259 2011-3720Vinnova
Note

QC 20130109

Available from: 2013-01-09 Created: 2013-01-08 Last updated: 2017-12-06Bibliographically approved

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Malkoch, Michael

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