An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations
2012 (English)In: The Journal of General Physiology, ISSN 0022-1295, Vol. 140, no 6, 587-594 p.Article in journal (Refereed) Published
Developing an understanding of the mechanism of voltage-gated ion channels in molecular terms requires knowledge of the structure of the active and resting conformations. Although the active-state conformation is known from x-ray structures, an atomic resolution structure of a voltage-dependent ion channel in the resting state is not currently available. This has motivated various efforts at using computational modeling methods and molecular dynamics (MD) simulations to provide the missing information. A comparison of recent computational results reveals an emerging consensus on voltage-dependent gating from computational modeling and MD simulations. This progress is highlighted in the broad context of preexisting work about voltage-gated channels.
Place, publisher, year, edition, pages
2012. Vol. 140, no 6, 587-594 p.
Shaker K+-Channel, Gated Sodium-Channel, Potassium Channel, Crystal-Structure, Electric-Field, Ion Channels, Structural Basis, Charge Movement, Sensor Domains, Lipid-Membrane
Bioinformatics and Systems Biology
IdentifiersURN: urn:nbn:se:kth:diva-116174DOI: 10.1085/jgp.201210873ISI: 000312957100004ScopusID: 2-s2.0-84871004046OAI: oai:DiVA.org:kth-116174DiVA: diva2:589421
FunderScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
QC 201301182013-01-182013-01-162013-02-01Bibliographically approved