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Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists
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2013 (English)In: MedChemComm, ISSN 2040-2503, E-ISSN 2040-2511, Vol. 4, no 1, 95-100 p.Article in journal (Refereed) Published
Abstract [en]

Improving aqueous solubility is a challenge frequently faced within drug discovery programs. Herein we describe increases in solubility in two sub-series of GPR119 agonists through reduction of lipophilicity together with hydrogen bond acceptor modulation. Small molecule X-ray crystallography was utilised to investigate effects on solid state interactions.

Place, publisher, year, edition, pages
2013. Vol. 4, no 1, 95-100 p.
Keyword [en]
Stimulated Insulin-Secretion, Medicinal Chemistry, Glycemic Control, Discovery, Potent, G-Protein-Coupled-Receptor-119, As1535907, Release, Agent
National Category
Biochemistry and Molecular Biology
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URN: urn:nbn:se:kth:diva-116417DOI: 10.1039/c2md20130eISI: 000312547200013Scopus ID: 2-s2.0-84871765871OAI: oai:DiVA.org:kth-116417DiVA: diva2:589917
Note

QC 20130121

Available from: 2013-01-21 Created: 2013-01-18 Last updated: 2017-12-06Bibliographically approved

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