Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists
2013 (English)In: MedChemComm, ISSN 2040-2503, Vol. 4, no 1, 95-100 p.Article in journal (Refereed) Published
Improving aqueous solubility is a challenge frequently faced within drug discovery programs. Herein we describe increases in solubility in two sub-series of GPR119 agonists through reduction of lipophilicity together with hydrogen bond acceptor modulation. Small molecule X-ray crystallography was utilised to investigate effects on solid state interactions.
Place, publisher, year, edition, pages
2013. Vol. 4, no 1, 95-100 p.
Stimulated Insulin-Secretion, Medicinal Chemistry, Glycemic Control, Discovery, Potent, G-Protein-Coupled-Receptor-119, As1535907, Release, Agent
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:kth:diva-116417DOI: 10.1039/c2md20130eISI: 000312547200013ScopusID: 2-s2.0-84871765871OAI: oai:DiVA.org:kth-116417DiVA: diva2:589917
QC 201301212013-01-212013-01-182013-01-21Bibliographically approved