Asymmetric Transfer Hydrogenation Coupled with Dynamic Kinetic Resolution in Water: Synthesis of anti-beta-Hydroxy-alpha-amino Acid Derivatives
2012 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 14, no 24, 6334-6337 p.Article in journal (Refereed) Published
The use of asymmetric transfer hydrogenation combined with dynamic kinetic resolution for the synthesis of beta-hydroxy-alpha-(tert-butoxycarbonyl)-amino esters in water is described. This procedure provides the desired amino alcohols in good yields, diastereoselectivities, and enantioselectivities. A surfactant is employed to achieve good yields due to the hydrophobic nature of both the catalyst and substrate. The reaction setup is operationally simple, and nondegassed water can be used as the solvent.
Place, publisher, year, edition, pages
2012. Vol. 14, no 24, 6334-6337 p.
Highly Enantioselective Synthesis, D-Erythro-Sphingosine, Organic-Synthesis, Aromatic Ketones, Aqueous-Media, Esters, Reduction, Catalyst, Depsipeptides, Complexes
IdentifiersURN: urn:nbn:se:kth:diva-116423DOI: 10.1021/ol303115vISI: 000312564500055ScopusID: 2-s2.0-84871570629OAI: oai:DiVA.org:kth-116423DiVA: diva2:589931
QC 201301212013-01-212013-01-182013-01-21Bibliographically approved