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Changes in circulating biomarkers during a single hemodialysis session
KTH, School of Technology and Health (STH), Medical Engineering.
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2013 (English)In: Hemodialysis International, ISSN 1492-7535, E-ISSN 1542-4758, Vol. 17, no 1, 59-66 p.Article in journal (Refereed) Published
Abstract [en]

The hemodialysis (HD) procedure induces an inflammatory response potentially contributing to cardiovascular disease. Here we investigated the acute impact of HD on circulating biomarkers. Circulating biomarkers (small solutes, middle molecular-sized peptides, and proteins) related to inflammation, oxidative stress, and vascular calcification (VC) were measured before and after a single session of HD in 45 clinically stable patients. Concentrations were corrected for ultrafiltration-induced hemoconcentration. Among vascular calcification-related biomarkers, osteoprotegerin and fetuin-A remained unchanged while fibroblast growth factor-23 (FGF23) decreased by -19%. Changes of FGF23 and changes of phosphate correlated (ρ=0.61, P<0.001). While C-reactive protein did not change, interleukin-6 (IL-6) increased by 14% and pentraxin 3 (PTX3) increased by 45%. IL-6 and PTX3 appear to be valid biomarkers of the intradialytic inflammatory response. VC-related markers were in general not affected by the single HD session; however, the observed correlation between acute changes of FGF-23 and phosphate during HD warrants further studies.

Place, publisher, year, edition, pages
2013. Vol. 17, no 1, 59-66 p.
Keyword [en]
Cardiovascular disease, Hemodialysis, Interleukin-6, Microinflammation, Pentraxin-3, Vascular calcification
National Category
Medical and Health Sciences
URN: urn:nbn:se:kth:diva-118131DOI: 10.1111/j.1542-4758.2012.00720.xISI: 000313751100008ScopusID: 2-s2.0-84872648128OAI: diva2:604900

QC 20130212

Available from: 2013-02-12 Created: 2013-02-12 Last updated: 2013-02-22Bibliographically approved

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Hayashi, Shirley Y.
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Medical Engineering
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