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Textile-enabled Bioimpedance Instrumentation for Personalised Health Monitoring Applications
KTH, School of Technology and Health (STH), Medical sensors, signals and systems (MSSS). (Applied Medical Technology - Electronics and sensors)
2013 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

A growing number of factors, including the costs, technological advancements, an ageing population, and medical errors are leading industrialised countries to invest in research on alternative solutions to improving their health care systems and increasing patients’ life quality. Personal Health System (PHS) solutions envision the use of information and communication technologies that enable a paradigm shift from the traditional hospital-centred healthcare delivery model toward a preventive and person-centred approach. PHS offers the means to follow patient health using wearable, portable or implantable systems that offer ubiquitous, unobtrusive bio-data acquisition, allowing remote access to patient status and treatment monitoring.

Electrical Bioimpedance (EBI) technology is a non-invasive, quick and relatively affordable technique that can be used for assessing and monitoring different health conditions, e.g., body composition assessments for nutrition. EBI technology combined with state-of-the-art advances in sensor and textile technology are fostering the implementation of wearable bioimpedance monitors that use functional garments for the implementation of personalised healthcare applications.

This research studies the development of a portable EBI spectrometer that can use dry textile electrodes for the assessment of body composition for the purposes of clinical uses. The portable bioimpedance monitor has been developed using the latest advances in system-on-chip technology for bioimpedance spectroscopy instrumentation. The obtained portable spectrometer has been validated against commercial spectrometer that performs total body composition assessment using functional textrode garments.

The development of a portable Bioimpedance spectrometer using functional garments and dry textile electrodes for body composition assessment has been shown to be a feasible option. The availability of such measurement systems bring closer the real implementation of personalised healthcare systems.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2013. , xvii, 48 p.
Series
Trita-STH : report, ISSN 1653-3836 ; 2013:1
Keyword [en]
personal healthcare systems, bioimpedance, wearable, portable, monitoring, textrodes, body composition, chronic kidney disease, ambient assisting living, wireless sensor
National Category
Medical Engineering Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:kth:diva-120373ISBN: 978-91-7501-702-0 (print)OAI: oai:DiVA.org:kth-120373DiVA: diva2:614469
Presentation
2013-04-29, A608, University of Borås, Borås, 10:00 (English)
Opponent
Supervisors
Note

QC 20130405

Available from: 2013-04-05 Created: 2013-04-04 Last updated: 2013-04-05Bibliographically approved
List of papers
1. An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications
Open this publication in new window or tab >>An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications
2008 (English)In: Physiological Measurement, ISSN 0967-3334, E-ISSN 1361-6579, Vol. 29, no 6, S267-78 p.Article in journal (Refereed) Published
Abstract [en]

The increasing number of applications of electrical bioimpedance measurements in biomedical practice, together with continuous advances in textile technology, has encouraged several researchers to make the first attempts to develop portable, even wearable, electrical bioimpedance measurement systems. The main target of these systems is personal and home monitoring. Analog Devices has made available AD5933, a new system-on-chip fully integrated electrical impedance spectrometer, which might allow the implementation of minimum-size instrumentation for electrical bioimpedance measurements. However, AD5933 as such is not suitable for most applications of electrical bioimpedance. In this work, we present a relatively simple analog front-end that adapts AD5933 to a four-electrode strategy, allowing its use in biomedical applications for the first time. The resulting impedance measurements exhibit a very good performance in aspects like load dynamic range and accuracy. This type of minimum-size, system-on-chip-based bioimpedance measurement system would lead researchers to develop and implement light and wearable electrical bioimpedance systems for home and personal health monitoring applications, a new and huge niche for medical technology development.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2008
Keyword
electrical bioimpedance spectroscopy; system-on-chip; four-electrode method
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:kth:diva-73057 (URN)10.1088/0967-3334/29/6/S23 (DOI)000257167200024 ()18544823 (PubMedID)
Note
QC 20120208Available from: 2012-02-08 Created: 2012-02-01 Last updated: 2017-12-08Bibliographically approved
2. AD5933-based spectrometer for electrical bioimpedance applications
Open this publication in new window or tab >>AD5933-based spectrometer for electrical bioimpedance applications
2010 (English)Conference paper, Published paper (Refereed)
Abstract [en]

To build an Electrical Bioimpedance (EBI) spectrometer using the Impedance Measurement System-On-Chip AD5933 together with a 4-Electrode Analog Front End (4E-AFE) has been proven practicable. Such small measurement devices can make possible several new applications of EBI technology, especially when combined with functional textiles, which can enable wearable applications for personal health and home monitoring. After the implementation and functional validation of the 4E-AFE-enabled spectrometer, the next natural step is to validate for which EBI applications the 4E-AFE-enabled system is suitable. To test the applicability of this novel spectrometer on several EBI applications, 2R1C equivalent models have been experimentally obtained and impedance spectroscopy measurements have been performed with the system under study and with the SFB7 EBI spectrometer manufactured by ImpediMed. The 2R1C circuit parameters have been estimated with the BioImp software from the spectra obtained with both EBI spectrometers and the estimated values have been compared with the original values used in each circuit model implementation. The obtained results indicated that the 4E-AFE-enabled system cannot beat the performance of the SFB7 in accuracy but it performs better in preciseness. In any case the overall performance indicates that the 4E-AFE-enabled system can perform spectroscopy measurements in the frequency range from 5 to 100 kHz.

Place, publisher, year, edition, pages
IOP Publishing, 2010
Series
Journal of Physics: Conference Series, ISSN 1742-6588
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:kth:diva-74410 (URN)10.1088/1742-6596/224/1/012011 (DOI)2-s2.0-77954670339 (Scopus ID)
Conference
International Conference on Electrical Bioimpedance
Note
QC 20120206Available from: 2012-02-06 Created: 2012-02-03 Last updated: 2017-05-17Bibliographically approved
3. AD5933-based electrical bioimpedance spectrometer: Towards textile-enabled applications
Open this publication in new window or tab >>AD5933-based electrical bioimpedance spectrometer: Towards textile-enabled applications
2011 (English)In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2011, Vol. 2011, 3282-3285 p.Conference paper, Published paper (Refereed)
Abstract [en]

Advances on System-On-Chip and Textile technology allows the development of Textile-enabled measurement instrumentation. Textile Electrodes (Textrodes) have been proven reliable for performing Electrical Bioimpedance Spectroscopy (EBIS) measurements, and the availability of a integrated circuit impedance spectrometer, the AD5933, has allowed the implementation of small size EBIS spectrometers. In this work an AD5933-based spectrometer has been implemented, and its performance on 2R1C circuits and for tetrapolar total right side EBIS measurements has been compared against the commercially available spectrometer SFB7. The study has been focused on the working upper frequency range and the estimation of the Cole parameters required for assessment of body fluid distribution: R(0) and R(∞). The results indicate that AD5933-based spectrometer implemented in this work can perform accurate impedance measurements well above the upper limits recommended in the datasheet. The AD5933-EBIS presents a good performance compared with the SFB7 on the 2R1C circuit and the total right side measurements, showing a smaller error in the resistance spectrum and small deviation error in the reactance when measuring over 270 kHz. The comparison on the Cole parameters estimation obtained with the SFB7 and the AD5933-based spectrometer exhibit a difference below 1% for the estimation of R(0) and R(∞). Consequently the overall measurement performance shown by the implemented AD5933-based spectrometer suggests its feasible use for EBIS measurements using dry Textrodes. This is of special relevance for the proliferation of EBI-based personalized health monitoring systems for patients that require to monitor the distribution of body fluids, like in dialysis.

National Category
Other Medical Engineering
Identifiers
urn:nbn:se:kth:diva-69633 (URN)10.1109/IEMBS.2011.6090891 (DOI)22255040 (PubMedID)2-s2.0-84055212203 (Scopus ID)
Conference
33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011; Boston, MA; 30 August 2011 through 3 September 2011
Note
QC 20120203Available from: 2012-01-29 Created: 2012-01-29 Last updated: 2017-05-17Bibliographically approved

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