Multilevel model based glucose control for type-1 diabetes patients
2013 (English)In: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2013, 3917-3920 p.Conference paper (Refereed)
Diabetes is a disease that involves alterationsat multiple biological levels, ranging from intracellular sig-nalling to organ processes. Since glucose homeostasis is theconsequence of complex interactions that involve a numberof factors, the control of diabetes should be based on amultilevel analysis. In this paper, a novel approach to designof closed-loop glucose controllers based on multilevel models ispresented. A control scheme is proposed based on combininga pharmacokinetic/pharmacodynamic model with an insulinsignal transduction model for type 1 diabetes mellitus patients.Based on this, an insulin feedback control schemes is designed.Two main advantages of explicitly utilizing information at theintracellular level were obtained. First, significant reductionof hypoglycaemic risk by reducing the undershoot in glucoselevels in response to added insulin. Second, robust performancefor inter-patient changes, demonstrated through application ofthe multilevel control strategy to a well establishedin silicopopulation of diabetic patients.
Place, publisher, year, edition, pages
2013. 3917-3920 p.
Glucose closed-loop control, Type 1 diabetes mellitus, PID
IdentifiersURN: urn:nbn:se:kth:diva-120489DOI: 10.1109/EMBC.2013.6610401ISI: 000341702104091ScopusID: 2-s2.0-84886457511ISBN: 978-145770216-7OAI: oai:DiVA.org:kth-120489DiVA: diva2:615423
35th Annual International IEEE EMBS Conference; Osaka International Convention Center, Osaka, Japan, July 3-7 2013
QC 201311182013-04-102013-04-102014-10-27Bibliographically approved