A chemo-mechanical constitutive model for transiently cross-linked actin networks and a theoretical assessment of their viscoelastic behaviour
2013 (English)In: Biomechanics and Modeling in Mechanobiology, ISSN 1617-7959, E-ISSN 1617-7940, Vol. 12, no 2, 373-382 p.Article in journal (Refereed) Published
Biological materials can undergo large deformations and also show viscoelastic behaviour. One such material is the network of actin filaments found in biological cells, giving the cell much of its mechanical stiffness. A theory for predicting the relaxation behaviour of actin networks cross-linked with the cross-linker alpha-actinin is proposed. The constitutive model is based on a continuum approach involving a neo-Hookean material model, modified in terms of concentration of chemically activated cross-links. The chemical model builds on work done by Spiros (Doctoral thesis, University of British Columbia, Vancouver, Canada, 1998) and has been modified to respond to mechanical stress experienced by the network. The deformation is split into a viscous and elastic part, and a thermodynamically motivated rate equation is assigned for the evolution of viscous deformation. The model predictions were evaluated for stress relaxation tests at different levels of strain and found to be in good agreement with experimental results for actin networks cross-linked with alpha-actinin.
Place, publisher, year, edition, pages
2013. Vol. 12, no 2, 373-382 p.
Viscoelasticity, alpha-actinin, Cross-link, Transient, Actin, Membrane
IdentifiersURN: urn:nbn:se:kth:diva-120524DOI: 10.1007/s10237-012-0406-7ISI: 000316283900014ScopusID: 2-s2.0-84880729830OAI: oai:DiVA.org:kth-120524DiVA: diva2:615578
QC 201304112013-04-112013-04-112015-12-09Bibliographically approved