Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Modeling of articular cartilage growth around localized defect-filling metal implant
KTH, School of Engineering Sciences (SCI), Mechanics, Structural Mechanics.
KTH, School of Engineering Sciences (SCI), Mechanics, Structural Mechanics.ORCID iD: 0000-0002-5819-4544
(English)In: Journal of Biomechanical Engineering, ISSN 0148-0731, E-ISSN 1528-8951Article in journal (Other academic) Submitted
National Category
Applied Mechanics
Identifiers
URN: urn:nbn:se:kth:diva-121569OAI: oai:DiVA.org:kth-121569DiVA: diva2:619123
Note

QCR 20161212

Available from: 2013-05-02 Created: 2013-05-02 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Mechanics and Growth of Articular Cartilage Around a Localized Metal Implant
Open this publication in new window or tab >>Mechanics and Growth of Articular Cartilage Around a Localized Metal Implant
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Articular cartilage is a specialized connective soft tissue that resides on the ends of long-bones, and transfers the load smoothly between the bones in diarthrodial joints by providing almost frictionless, wear resistant sliding surfaces during joint articulation. Focal chondral or osteochondral defects in articular cartilage are common and show limited capacity for biological repair. Furthermore, changes in the bio-mechanical forces at the defect site may make the tissue more susceptible to continued degeneration. Alternatively, a contoured focal resurfacing metal implant can be used to treat such full-thickness cartilage defects. Physiological and biomechanical studies on animal models with metal implant have shown good clinical outcomes. However, the mechanical behavior of cartilage surrounding the implant has remained largely unanswered with respect to the joint function.

First, we developed a simple 3-dimensional finite element model by approximating one of the condyles of a sheep knee joint and parametrically studied the effects of shape, size and positioning of the implant on the mechanical behavior of the cartilage surrounding the implant. The mechanical sealing effect due to the wedge shape of the implant was studied. We also simulated the time dependent behavior of the cartilage surrounding the implant. In the second part, we developed a more sophisticated model accounting for biological growth aspects of the cartilage around the implant together with the in vivo mechanical response of the cartilage in an intact human knee joint. An axisymmetric representation of a human knee condyle including both cartilage layers, meniscus and tibia was considered. A cartilage growth finite element model incorporating dynamic loading from walking, which drives the growth stimulation in the cartilage, was developed. Two individually growing constituents in the solid matrix of cartilage together with the biphasic contacts in the joint were considered in the growth model. From our simulations it is evident that the cartilage near the implant was more stimstimulated, whence the defect edge of the cartilage was growing onto the implant.

The models developed in the present work are simulation tools and have a potential, in relevant aspects, to predict the physiological behavior of the cartilage surrounding the metal implant.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2013. x, 48 p.
Series
Trita-MEK, ISSN 0348-467X ; 2013:08
Keyword
finite element analysis, articular cartilage defects, growth, knee, focal knee resurfacing, metal implant, poroelastic, porohyperelastic, biphasic
National Category
Applied Mechanics
Identifiers
urn:nbn:se:kth:diva-121573 (URN)978-91-7501-720-4 (ISBN)
Public defence
2013-05-22, F3, Lindstedtsvägen 26, Lindstedtsvägen 26, KTH, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

QC 20130502

Available from: 2013-05-02 Created: 2013-05-02 Last updated: 2013-05-08Bibliographically approved

Open Access in DiVA

No full text

Authority records BETA

Eriksson, Anders

Search in DiVA

By author/editor
Manda, KrishnagoudEriksson, Anders
By organisation
Structural Mechanics
In the same journal
Journal of Biomechanical Engineering
Applied Mechanics

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 152 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf