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Identification of carotid plaque tissue properties using an experimental-numerical approach
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Biomechanics.
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Biomechanics.
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2013 (English)In: Journal of The Mechanical Behavior of Biomedical Materials, ISSN 1751-6161, E-ISSN 1878-0180, Vol. 27, 226-238 p.Article in journal (Refereed) Published
Abstract [en]

A biomechanical stress analysis could help to identify carotid plaques that are vulnerable to rupture, and hence reduce the risk of thrombotic strokes. Mechanical stress predictions critically depend on the plaque's constitutive properties, and the present study introduces a concept to derive viscoelastic parameters through an experimental-numerical approach. Carotid plaques were harvested from two patients during carotid endarterectomy (CEA), and, in total, nine test specimens were investigated. A novel in-vitro mechanical testing protocol, which allows for dynamic testing, keeping the carotid plaque components together, was introduced. Macroscopic pictures overlaid by histological stains allowed for the segmentation of plaque tissues, in order to develop high-fidelity and low-fidelity Finite Element Method (FEM) models of the test specimens. The FEM models together with load-displacement data from the mechanical testing were used to extract constitutive parameters through inverse parameter estimation. The applied inverse parameter estimation runs in stages, first addressing the hyperelastic parameters then the viscoelastic ones. Load-displacement curves from the mechanical testing showed strain stiffening and viscoelasticity, as is expected for both normal and diseased carotid tissue. The estimated constitutive properties of plaque tissue were comparable to previously reported studies, Due to the highly non-linear elasticity of vascular tissue, the applied parameter estimation approach is, as with many similar approaches, sensitive to the initial guess of the parameters.

Place, publisher, year, edition, pages
2013. Vol. 27, 226-238 p.
Keyword [en]
Carotid plaque, Nonlinear, Constitutive description, Viscoelasticity, Vascular tissue
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-122850DOI: 10.1016/j.jmbbm.2013.05.001ISI: 000325304700021Scopus ID: 2-s2.0-84884281688OAI: oai:DiVA.org:kth-122850DiVA: diva2:623601
Funder
Swedish Research Council, 2010-4446
Note

QC 20131107. Updated from accepted to published.

Available from: 2013-05-28 Created: 2013-05-28 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Failure of vascular tissue with applications to the aneurysm wall, carotid plaque and myocardial tissue
Open this publication in new window or tab >>Failure of vascular tissue with applications to the aneurysm wall, carotid plaque and myocardial tissue
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Cardiovascular disease is the leading cause of death in the modern world. Examples are thoracic aortic aneurysm (TAA), abdominal aortic aneurysm (AAA) and stroke due to plaque rupture. Failure in soft tissues caused by medical devices is also a medical challenge. In all these cardiovascular events a better prediction of failure of the tissue and a better understanding about the tissue properties will help in predicament and treatment. For example the diameter-based indication for surgical repair of AAA and TAAs is not sufficient and refined methods are needed. In this thesis failures of some soft vascular tissues, was studied. Experiments have been combined with numerical modeling to understand the elastic and failure properties of AAA, TAA and plaque tissue as well as the ventricular wall. Vascular tissue is anisotropic, time-dependent, nonlinear and shows large deformations. Among others this thesis showed the importance of viscoelasticity which motivates to develop a new continuum mechanical framework. In addition a large part of this thesis dealt with anisotropy of vascular tissue. For the first time the collagen orientation distribution in the AAA wall has been identified. Collagen and its distribution orientation is also an important feature of this tissue. There was a correlation between the strength and stiffness of the AAA samples with the decreasing wall thickness. Increased stiffness was found in the aortic wall of patients with chronic obstructive pulmonary disease (COPD) compared to patients that did not have COPD. As well as difference in stiffness of TAA tissue, in patients with non-pathologic and pathologic aortic valves. Some of the findings in this thesis could have a long-term consequence for management of risk of rupture in AAA, TAA and plaque.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2013. x, 30 p.
Series
Trita-HFL, ISSN 1104-6813 ; 0545
National Category
Other Mechanical Engineering
Identifiers
urn:nbn:se:kth:diva-122840 (URN)978-91-7501-798-3 (ISBN)
Public defence
2013-06-07, Sal D2, Lindstedtsvägen 5, KTH, Stockholm, 09:00 (English)
Opponent
Supervisors
Note

QC 20130528

Available from: 2013-05-28 Created: 2013-05-28 Last updated: 2013-05-29Bibliographically approved

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