Baroreflex impairment during rapid posture changes at rest and exercise after 120 days of bed rest.
2006 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 96, no 1, 37-45 p.Article in journal (Refereed) Published
Orthostatic intolerance is common after space flight and head-down tilt (HDT) bed rest. We hypothesized that HDT-induced impairments of arterial blood pressure (AP) control would be more marked during exercise and that recovery of baroreflex function after very long-term HDT would be delayed. Six subjects were studied before (BDC) during (day 60, D60; D113) and after (recovery day 0, R0; R3; R15) 120 days of HDT. Supine resting subjects were exposed to repeated 1 min passive tilts to upright at 3-min interval. During 50 W steady-state exercise corresponding tilt had a 2-min duration at 4-min interval. The amplitudes of the tilt-induced transient beat-by-beat deviations in AP and rate (HR) were determined during the gravity transients. At rest these deviations did not change over time, but during exercise the total peak-to-nadir range of deviations in systolic AP (SAP) at up-tilt and down-tilt increased to 168+/-16% (mean+/-SEM) of BDC at D113 with no clear recovery upto and including R15. Counter-regulatory HR responses were not increased proportionally and especially not tachycardic responses to up-tilt, resulting in a reduction of baroreflex sensitivity (deltaRR-interval/deltaSAP) by 55+/-9% of BDC at D113 with no recovery upto and including R15. We conclude that prolonged bed rest cause long-lasting impairments in AP control and baroreflex function in exercising humans.
Place, publisher, year, edition, pages
2006. Vol. 96, no 1, 37-45 p.
simulated microgravity, head down tilt; tilt, arterial blood pressure
IdentifiersURN: urn:nbn:se:kth:diva-123228DOI: 10.1007/s00421-005-0062-zISI: 000233722300006ScopusID: 2-s2.0-29544435097OAI: oai:DiVA.org:kth-123228DiVA: diva2:625528
QC 201306102013-06-052013-06-052016-04-27Bibliographically approved