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Impaired pressor response after spaceflight and bed rest: evidence for cardiovascular dysfunction.
KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).ORCID iD: 0000-0001-6361-8965
2001 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 85, no 1-2, p. 49-55Article in journal (Refereed) Published
Abstract [en]

We hypothesized that impaired cardiovascular responses to isometric muscle action contribute to the cardiovascular deconditioning that occurs after space flight (SF) and head-down-tilt bed rest (HDT). Six subjects were studied before, during and after 120 days of -6 degrees HDT, and four subjects were studied before, during (two subjects) and after 179-389 days of SF. Subjects performed a sustained handgrip (SHG) at a force equivalent to 30% of maximum contraction force for 2 min, and heart-rate (HR) and pressor (mean arterial pressure, deltaMAP) responses were recorded. At the same relative force, both deltaHR and deltaMAP were significantly reduced during the first days after HDT (-54%, P<0.05 and -43%, P<0.05). In two subjects studied within 24 h after their return from SF, deltaMAP was practically absent (-79%, P<0.05) whereas in four subjects studied 1-4 days after return from SF, deltaMAP was reduced by 35% (P<0.05). deltaHR was not significantly changed. Our finding of attenuated pressor responses to SHG after HDT and SF supports the notion of impairments at both the neurocirculatory control and effector organ levels.

Place, publisher, year, edition, pages
2001. Vol. 85, no 1-2, p. 49-55
National Category
Physiology
Identifiers
URN: urn:nbn:se:kth:diva-123241DOI: 10.1007/s004210100429OAI: oai:DiVA.org:kth-123241DiVA, id: diva2:625561
Note
NR 20140805Available from: 2013-06-05 Created: 2013-06-05 Last updated: 2018-01-11Bibliographically approved

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