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Cardiovascular responses to upright and supine exercise in humans after 6 weeks of head-down tilt (-6 degrees).
KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).ORCID iD: 0000-0001-6361-8965
2000 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 83, no 4-5, 303-309 p.Article in journal (Refereed) Published
Abstract [en]

Seven healthy men performed steady-state dynamic leg exercise at 50 W in supine and upright postures, before (control) and repeatedly after 42 days of strict head-down tilt (HDT) (-6 degrees) bedrest. Steady-state heart rate (fc), mean arterial blood pressure, cardiac output (Qc), and stroke volume (SV) were recorded. The following data changed significantly from control values. The fc was elevated in both postures at least until 12 days, but not at 32 days after bedrest. Immediately after HDT, SV and Qc were decreased by 25 (SEM 3)% and 19 (SEM 3)% in supine, and by 33 (SEM 5)% and 20 (SEM 3)% in upright postures, respectively. Within 2 days there was a partial recovery of SV in the upright but not in the supine posture. The SV and Qc during supine exercise remained significantly decreased for at least a month. Submaximal oxygen uptake did not change after HDT. We concluded that the cardiovascular response to exercise after prolonged bedrest was impaired for so long that it suggested that structural cardiac changes had developed during the HDT period.

Place, publisher, year, edition, pages
2000. Vol. 83, no 4-5, 303-309 p.
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URN: urn:nbn:se:kth:diva-123243DOI: 10.1007/s004210000258OAI: diva2:625564
NR 20140805Available from: 2013-06-05 Created: 2013-06-05 Last updated: 2014-01-20Bibliographically approved

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Sundblad, Patrik
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Environmental Physiology (Closed 20130701)
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