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Comparative characterization of oligomeric precursors intended for injectable implants
Department of Materials Chemistry, Division of Polymer Chemistry, The Ångström Laboratory, Uppsala University, Sweden .ORCID iD: 0000-0003-1161-9311
2013 (English)In: Polymers for Advanced Technologies, ISSN 1042-7147, E-ISSN 1099-1581, Vol. 24, no 1, 15-21 p.Article in journal (Refereed) Published
Abstract [en]

The use of injectable materials is a simple approach for drug delivery and tissue repair, in, e. g. minimally invasive surgery applications. If these materials are used past their glass transition temperature and have a low viscosity, they will be able to flow while delivered in situ. Whether these materials are to be used as low viscosity drug carriers or further crosslinked for tissue repair, there is a need for a better understanding of their handling properties. In this study, oligo(trimethylene carbonate) (oTMC) and oligo[D, L-lactide-co-(epsilon-caprolactone)] (oDLLA-co-CL) of various molecular weights within a relevant injectability range were synthesized via ring-opening polymerization. The materials were comparatively characterized by H-1 NMR spectroscopy, differential scanning calorimetry, gel permeation chromatography, and rheological measurements. After comparing the viscosities and molecular weights of the materials, it was concluded that oDLLA-co-CLs were, generally, better suited as an injectable in situ crosslinking network, whereas oTMCs were found to be better candidates as injectable drug carriers. This study provides useful data and guidelines on the use of these and other similar oligomers intended for injectable implants.

Place, publisher, year, edition, pages
2013. Vol. 24, no 1, 15-21 p.
Keyword [en]
oligomer(s), polyester(s), polycarbonate(s), rheology, injectable implant(s)
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-124758DOI: 10.1002/pat.3042ISI: 000312887500005OAI: oai:DiVA.org:kth-124758DiVA: diva2:638405
Note

QC 20130813

Available from: 2013-07-30 Created: 2013-07-30 Last updated: 2017-12-06Bibliographically approved

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Rojas, Ramiro

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