Molecular design and evaluation of biodegradable polymers using a statistical approach
2013 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 24, no 11, 2529-2535 p.Article in journal (Refereed) Published
The challenging paradigm of bioresorbable polymers, whether in drug delivery or tissue engineering, states that a fine-tuning of the interplay between polymer properties (e.g., thermal, degradation), and the degree of cell/tissue replacement and remodeling is required. In this paper we describe how changes in the molecular architecture of a series of terpolymers allow for the design of polymers with varying glass transition temperatures and degradation rates. The effect of each component in the terpolymers is quantified via design of experiment (DoE) analysis. A linear relationship between terpolymer components and resulting T-g (ranging from 34 to 86 A degrees C) was demonstrated. These findings were further supported with mass-per-flexible-bond analysis. The effect of terpolymer composition on the in vitro degradation of these polymers revealed molecular weight loss ranging from 20 to 60 % within the first 24 h. DoE modeling further illustrated the linear (but reciprocal) relationship between structure elements and degradation for these polymers. Thus, we describe a simple technique to provide insight into the structure property relationship of degradable polymers, specifically applied using a new family of tyrosine-derived polycarbonates, allowing for optimal design of materials for specific applications.
Place, publisher, year, edition, pages
2013. Vol. 24, no 11, 2529-2535 p.
Tyrosine-Derived Polycarbonates, Poly(Ethylene Glycol), In-Vitro, Hydrolytic Degradation, High-Throughput, Biomaterials, Combinatorial, Bone, Technologies, Copolymers
IdentifiersURN: urn:nbn:se:kth:diva-124761DOI: 10.1007/s10856-013-5008-0ISI: 000326049900005ScopusID: 2-s2.0-84887198898OAI: oai:DiVA.org:kth-124761DiVA: diva2:638409
QC 201506292013-07-302013-07-302015-06-29Bibliographically approved