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DNA methylation: the future of crime scene investigation?
KTH, School of Biotechnology (BIO), Gene Technology.
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2013 (English)In: Molecular Biology Reports, ISSN 0301-4851, E-ISSN 1573-4978, Vol. 40, no 7, 4349-4360 p.Article in journal (Refereed) Published
Abstract [en]

Proper detection and subsequent analysis of biological evidence is crucial for crime scene reconstruction. The number of different criminal acts is increasing rapidly. Therefore, forensic geneticists are constantly on the battlefield, trying hard to find solutions how to solve them. One of the essential defensive lines in the fight against the invasion of crime is relying on DNA methylation. In this review, the role of DNA methylation in body fluid identification and other DNA methylation applications are discussed. Among other applications of DNA methylation, age determination of the donor of biological evidence, analysis of the parent-of-origin specific DNA methylation markers at imprinted loci for parentage testing and personal identification, differentiation between monozygotic twins due to their different DNA methylation patterns, artificial DNA detection and analyses of DNA methylation patterns in the promoter regions of circadian clock genes are the most important ones. Nevertheless, there are still a lot of open chapters in DNA methylation research that need to be closed before its final implementation in routine forensic casework.

Place, publisher, year, edition, pages
Springer Netherlands, 2013. Vol. 40, no 7, 4349-4360 p.
Keyword [en]
Epigenetics, DNA methylation, Body fluid identification, DNA methylation applications, Forensic science
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-124967DOI: 10.1007/s11033-013-2525-3ISI: 000320674700028ScopusID: 2-s2.0-84879417560OAI: diva2:638923

QC 20130805

Available from: 2013-08-05 Created: 2013-08-02 Last updated: 2013-08-05Bibliographically approved

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Vickovic, Sanja
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