Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The genomics of selection in dogs and the parallel evolution between dogs and humans
Show others and affiliations
2013 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 4, 1860- p.Article in journal (Refereed) Published
Abstract [en]

The genetic bases of demographic changes and artificial selection underlying domestication are of great interest in evolutionary biology. Here we perform whole-genome sequencing of multiple grey wolves, Chinese indigenous dogs and dogs of diverse breeds. Demographic analysis show that the split between wolves and Chinese indigenous dogs occurred 32,000 years ago and that the subsequent bottlenecks were mild. Therefore, dogs may have been under human selection over a much longer time than previously concluded, based on molecular data, perhaps by initially scavenging with humans. Population genetic analysis identifies a list of genes under positive selection during domestication, which overlaps extensively with the corresponding list of positively selected genes in humans. Parallel evolution is most apparent in genes for digestion and metabolism, neurological process and cancer. Our study, for the first time, draws together humans and dogs in their recent genomic evolution.

Place, publisher, year, edition, pages
Nature Publishing Group, 2013. Vol. 4, 1860- p.
Keyword [en]
animal experiment, article, biological phenomena and functions concerning the entire organism, breed, Chinese, controlled study, demography, digestion, dog, domestication, evolution, gene sequence, genetic selection, genomics, human, human genome, metabolism, neoplasm, neurology, nonhuman
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-124994DOI: 10.1038/ncomms2814ISI: 000320589900056Scopus ID: 2-s2.0-84878742437OAI: oai:DiVA.org:kth-124994DiVA: diva2:638976
Funder
Knut and Alice Wallenberg FoundationScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20130805

Available from: 2013-08-05 Created: 2013-08-02 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Authority records BETA

Savolainen, Peter

Search in DiVA

By author/editor
Savolainen, Peter
By organisation
Gene TechnologyScience for Life Laboratory, SciLifeLab
In the same journal
Nature Communications
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 126 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf