Oxygen plasma functionalization of parylene C coating for implants surface: Nanotopography and active sites for drug anchoring
2013 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, Vol. 33, no 7, 4221-4227 p.Article in journal (Refereed) Published
The effect of oxygen plasma treatment (t = 0.1-60 min, pO2 = 0.2 mbar, P = 50 W) of parylene C implant surface coating was investigated in order to check its influence on morphology (SEM, AFM observations), chemical composition (XPS analysis), hydrophilicity (contact angle measurements) and biocompatibility (MG-63 cell line and Staphylococcus aureus 24167 DSM adhesion screening). The modification procedure leads to oxygen insertion (up to 20 at.%) into the polymer matrix and together with surface topography changes has a dramatic impact on wettability (change of contact angle from θ = 78 ± 2 to θ = 33 ± 1.9 for unmodified and 60 min treated sample, respectively). As a result, the hydrophilic surface of modified parylene C promotes MG-63 cells growth and at the same time does not influence S. aureus adhesion. The obtained results clearly show that the plasma treatment of parylene C surface provides suitable polar groups (C = O, C-O, O-C = O, C-O-O and O-C(O)-O) for further development of the coating functionality.
Place, publisher, year, edition, pages
2013. Vol. 33, no 7, 4221-4227 p.
Implant surface, MG-63 cells, Oxygen plasma treatment, Parylene C, Staphylococcus aureus
Engineering and Technology
IdentifiersURN: urn:nbn:se:kth:diva-126041DOI: 10.1016/j.msec.2013.06.014ISI: 000325445700086ScopusID: 2-s2.0-84881146938OAI: oai:DiVA.org:kth-126041DiVA: diva2:641752
QC 201308192013-08-192013-08-192013-11-08Bibliographically approved