Exploiting the nano-sized features of microfibrillated cellulose (MFC) for the development of controlled-release packaging
2013 (English)In: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 110, 208-216 p.Article in journal (Refereed) Published
Microfibrillated cellulose (MFC) was used in this study to prepare films containing an active molecule, lysozyme, which is a natural antimicrobial agent. The main goal of this research was to assess the potential for exploiting the nano-sized dimension of cellulose fibrils to slow the release of the antimicrobial molecule, thus avoiding a too-quick release into the surrounding medium, which is a major disadvantage of most release systems. For this purpose, the release kinetics of lysozyme over a 10-day period in two different media (pure water and water/ethanol 10. wt.%) were obtained, and the experimental data was fitted with a solution of Fick's second law to quantify the apparent diffusion coefficient (D). The results indicate that the MFC retained lysozyme, presumably due to electrostatic, hydrogen, and ion-dipole interactions, with the largest release of lysozyme-approximately 14%-occurring from the initial amount loaded on the films. As expected, ethanol as a co-solvent slightly decreased the diffusion of lysozyme from the MFC polymer network. The addition of two potential modulating release agents-glycerol and sodium chloride-was also evaluated. Findings from this work suggest that MFC-based films can be considered a suitable candidate for use in controlled-release packaging systems.
Place, publisher, year, edition, pages
2013. Vol. 110, 208-216 p.
Controlled release, Diffusion, Lysozyme, Microfibrillated cellulose, Modeling, Nano-sized
IdentifiersURN: urn:nbn:se:kth:diva-126039DOI: 10.1016/j.colsurfb.2013.04.046ISI: 000321940200028ScopusID: 2-s2.0-84878939688OAI: oai:DiVA.org:kth-126039DiVA: diva2:641786
QC 201308192013-08-192013-08-192013-08-23Bibliographically approved