Change search
ReferencesLink to record
Permanent link

Direct link
Correlation between human natural killer cell migration and cytotoxicity.
KTH, School of Engineering Sciences (SCI), Applied Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics.
2013 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Natural killer cells constitute part of the innate immune system, defending

against cancer tumours and infections. Ongoing research has shown a diering

e-ciency to kill target cells among individual cells in natural killer cell

populations, and new tools allow for in-depth studies of large cell numbers over

an extended period of time.

In this thesis, the killing e-ciency of natural killer cells is correlated with

their migration behaviour. Migratory properties are found to be of either of

two essentially dierent forms, being active or inactive, and killing e-ciency

is demonstrated to not be strongly related to migration behaviour. Further,

natural killer cell populations are shown to exhibit additional heterogeneity as

cells inducing fast death of target cells are shown to dier in migration compared

to cells inducing slow death. Lastly, cells showing exhaustion in cytotoxicity

during the assay are demonstrated to also experience migratory exhaustion.

Place, publisher, year, edition, pages
2013. , 32 p.
National Category
Engineering and Technology
URN: urn:nbn:se:kth:diva-126487OAI: diva2:642343
Available from: 2013-08-21 Created: 2013-08-21 Last updated: 2013-08-21Bibliographically approved

Open Access in DiVA

Ksenia Chechet, Oscar Michelin kandidatex,-rapport(3752 kB)129 downloads
File information
File name FULLTEXT01.pdfFile size 3752 kBChecksum SHA-512
Type fulltextMimetype application/pdf

By organisation
Applied Physics
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
Total: 129 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 87 hits
ReferencesLink to record
Permanent link

Direct link