Natural killer cells constitute part of the innate immune system, defending
against cancer tumours and infections. Ongoing research has shown a diering
e-ciency to kill target cells among individual cells in natural killer cell
populations, and new tools allow for in-depth studies of large cell numbers over
an extended period of time.
In this thesis, the killing e-ciency of natural killer cells is correlated with
their migration behaviour. Migratory properties are found to be of either of
two essentially dierent forms, being active or inactive, and killing e-ciency
is demonstrated to not be strongly related to migration behaviour. Further,
natural killer cell populations are shown to exhibit additional heterogeneity as
cells inducing fast death of target cells are shown to dier in migration compared
to cells inducing slow death. Lastly, cells showing exhaustion in cytotoxicity
during the assay are demonstrated to also experience migratory exhaustion.
2013. , 32 p.