Side-by-side comparison of dendritic-linear hybrids and their hyperbranched analogs as micellar carriers of chemotherapeutics
2013 (English)In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 51, no 19, 3992-3996 p.Article in journal (Refereed) Published
Amphiphilic block copolymers are successfully synthesized possessing a hydrophobic dendritic component based on the bis-MPA monomer and a hydrophilic linear polyethylene glycol (PEG) component. The hybrids were either conjured in small scale using robust click reactions between perfect dendrons and linear PEG or multigram polycondensation of hyperbranched blocks from PEG. In all cases, the amphiphiles were assembled to micelles, were found nontoxic and successfully loaded with the chemotherapeutic doxorubicin.
Place, publisher, year, edition, pages
2013. Vol. 51, no 19, 3992-3996 p.
amphiphilic, biocompatibility, 2, 2-bis(hydroxymethyl)propionic acid, bis-MPA, block copolymers, click chemistry, dendritic-linear hybrids, drug delivery, micelles, synthesis
IdentifiersURN: urn:nbn:se:kth:diva-127462DOI: 10.1002/pola.26825ISI: 000323654300002ScopusID: 2-s2.0-84883208788OAI: oai:DiVA.org:kth-127462DiVA: diva2:644402
FunderVinnovaSwedish Research Council, 2011-3720 2010-453 2009-3259
QC 201310042013-08-302013-08-302013-10-04Bibliographically approved