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Integration of microfluidics with grating coupled silicon photonic sensors by one-step combined photopatterning and molding of OSTE
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-6443-878X
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2013 (English)In: Optics Express, ISSN 1094-4087, Vol. 21, no 18, 21293-21298 p.Article in journal (Refereed) Published
Abstract [en]

We present a novel integration method for packaging silicon photonic sensors with polymer microfluidics, designed to be suitable for wafer-level production methods. The method addresses the previously unmet manufacturing challenges of matching the microfluidic footprint area to that of the photonics, and of robust bonding of microfluidic layers to biofunctionalized surfaces. We demonstrate the fabrication, in a single step, of a microfluidic layer in the recently introduced OSTE polymer, and the subsequent unassisted dry bonding of the microfluidic layer to a grating coupled silicon photonic ring resonator sensor chip. The microfluidic layer features photopatterned through holes (vias) for optical fiber probing and fluid connections, as well as molded microchannels and tube connectors, and is manufactured and subsequently bonded to a silicon sensor chip in less than 10 minutes. Combining this new microfluidic packaging method with photonic waveguide surface gratings for light coupling allows matching the size scale of microfluidics to that of current silicon photonic biosensors. To demonstrate the new method, we performed successful refractive index measurements of liquid ethanol and methanol samples, using the fabricated device. The minimum required sample volume for refractive index measurement is below one nanoliter.

Place, publisher, year, edition, pages
Optical Society of America, 2013. Vol. 21, no 18, 21293-21298 p.
Keyword [en]
biosensor, microfluidics, oste
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
URN: urn:nbn:se:kth:diva-127716DOI: 10.1364/oe.21.021293ISI: 000324867100092ScopusID: 2-s2.0-84884552942OAI: diva2:645573
Swedish Research Council, B0460801EU, European Research Council, 267528

This paper was published in Optics Express and is made available as an electronic reprint with the permission of OSA.  The paper can be found at the following URL on the OSA website: Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.

Qc 20130913

Available from: 2013-09-04 Created: 2013-09-04 Last updated: 2015-04-29Bibliographically approved
In thesis
1. Integrating Biosensors for Air Monitoring and Breath-Based Diagnostics
Open this publication in new window or tab >>Integrating Biosensors for Air Monitoring and Breath-Based Diagnostics
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The air we breathe is the concern of all of us but nevertheless we only know very little about airborne particles, and especially which biological microorganisms they contain. Today, we live in densely populated societies with a growing number of people, making us particularly vulnerable to air transmission of pathogens. With the recent appearance of highly pathogenic types of avian influenza in southeast Asia and the seasonal outbreaks of gastroenteritis caused by the extremely contagious norovirus, the need for portable, sensitive and rapid instruments for on-site detection and monitoring of airborne pathogens is apparent.

Unfortunately, the integration incompatibility between state-of-the-art air sampling techniques and laboratory based analysis methods makes instruments for in-the-field rapid detection of airborne particles an unresolved challenge.

This thesis aims at addressing this challenge by the development of novel manufacturing, integration and sampling techniques to enable the use of label-free biosensors for rapid and sensitive analysis of airborne particles at the point-of-care or in the field.

The first part of the thesis introduces a novel reaction injection molding technique for the fabrication of high quality microfluidic cartridges. In addition, electrically controlled liquid aspiration and dispensing is presented, based on the use of a thermally actuated polymer composite integrated with microfluidic cartridges.

The second part of the thesis demonstrates three different approaches of biosensor integration with microfluidic cartridges, with a focus on simplifying the design and integration to enable disposable use of the cartridges.

The third part to the thesis presents a novel air sampling technique based on electrophoretic transport of airborne particles directly to microfluidic cartridges. This technique is enabled by the development of a novel microstructured component for integrated air-liquid interfacing. In addition, a method for liquid sample mixing with magnetic microbeads prior to downstream biosensing is demonstrated.In the fourth part of the thesis, three different applications for airborne particle biosensing are introduced and preliminary experimental results are presented.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2015. xix, 85 p.
TRITA-EE, ISSN 1653-5146 ; 2015:020
National Category
Medical Laboratory and Measurements Technologies
urn:nbn:se:kth:diva-165454 (URN)978-91-7595-560-5 (ISBN)
Public defence
2015-05-22, Q2, Osquldas väg 10, KTH, Stockholm, 10:00 (English)
EU, FP7, Seventh Framework ProgrammeVINNOVASwedish Research CouncilSwedish Foundation for Strategic Research

QC 20150429

Available from: 2015-04-29 Created: 2015-04-28 Last updated: 2015-04-29Bibliographically approved

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