Influence of myocardial fiber/sheet orientations on left ventricular mechanical contraction
2013 (English)In: Mathematics and mechanics of solids, ISSN 1081-2865, E-ISSN 1741-3028, Vol. 18, no 6, 592-606 p.Article in journal (Refereed) Published
At any point in space the material properties of the myocardium are characterized as orthotropic, that is, there are three mutually orthogonal axes along which both electrical and mechanical parameters differ. To investigate the role of spatial structural heterogeneity in an orthotropic material, electro-mechanically coupled models of the left ventricle (LV) were used. The implemented models differed in their arrangement of fibers and sheets in the myocardium, but were identical otherwise: (i) a generic homogeneous model, where a rule-based method was applied to assign fiber and sheet orientations, and (ii) a heterogeneous model, where the assignment of the orthotropic tissue structure was based on experimentally obtained fiber/sheet orientations. While both models resulted in pressure-volume loops and metrics of global mechanical function that were qualitatively and quantitatively similar and matched well with experimental data, the predicted deformations were strikingly different between these models, particularly with regard to torsion. Thus, the simulation results strongly suggest that heterogeneous structure properties play an important nonnegligible role in LV mechanics and, consequently, should be accounted for in computational models.
Place, publisher, year, edition, pages
2013. Vol. 18, no 6, 592-606 p.
Electro-mechanics, mono-domain, weak coupling, PV loops
Engineering and Technology
IdentifiersURN: urn:nbn:se:kth:diva-127762DOI: 10.1177/1081286513485779ISI: 000323118900004ScopusID: 2-s2.0-84882319758OAI: oai:DiVA.org:kth-127762DiVA: diva2:646011
QC 201309062013-09-062013-09-052013-09-06Bibliographically approved