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Estimation of body fluids with bioimpedance spectroscopy: state of the art methods and proposal of novel methods
KTH, School of Technology and Health (STH), Medical sensors, signals and systems (MSSS) (Closed 20130701). University of Alcala, Spain; Chalmers University of Technology, Sweden; University of Boras, Sweden.
KTH, School of Technology and Health (STH), Medical sensors, signals and systems (MSSS) (Closed 20130701). University of Boras, Sweden.ORCID iD: 0000-0002-6995-967X
KTH, School of Technology and Health (STH), Medical sensors, signals and systems (MSSS) (Closed 20130701). University of Boras, Sweden; Karolinska Instituet, Sweden.
University of Gothenburg.
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2015 (English)In: Physiological Measurement, ISSN 0967-3334, E-ISSN 1361-6579, Vol. 36, no 10Article in journal (Refereed) Published
Abstract [en]

Determination of body fluids is a useful common practice in determination of disease mechanisms and treatments. Bioimpedance spectroscopy (BIS) methods are non-invasive, inexpensive and rapid alternatives to reference methods such as tracer dilution. However, they are indirect and their robustness and validity are unclear. In this article, state of the art methods are reviewed, their drawbacks identified and new methods are proposed. All methods were tested on a clinical database of patients receiving growth hormone replacement therapy. Results indicated that most BIS methods are similarly accurate (e.g. < 0.5 +/- 3.0% mean percentage difference for total body water) for estimation of body fluids. A new model for calculation is proposed that performs equally well for all fluid compartments (total body water, extra-and intracellular water). It is suggested that the main source of error in extracellular water estimation is due to anisotropy, in total body water estimation to the uncertainty associated with intracellular resistivity and in determination of intracellular water a combination of both.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2015. Vol. 36, no 10
Keyword [en]
bioimpedance, body composition, body fluids estimation
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:kth:diva-128807DOI: 10.1088/0967-3334/36/10/2171ISI: 000367690500013Scopus ID: 2-s2.0-84947596900OAI: oai:DiVA.org:kth-128807DiVA: diva2:648789
Note

Updated from manuscript to article in journal.

QC 20160201

Available from: 2013-09-17 Created: 2013-09-17 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Improvements in Bioimpedance SpectroscopyData Analysis: Artefact Correction, ColeParameters, and Body Fluid Estimation
Open this publication in new window or tab >>Improvements in Bioimpedance SpectroscopyData Analysis: Artefact Correction, ColeParameters, and Body Fluid Estimation
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The estimation of body fluids is a useful and common practice in the status assessment of diseasemechanisms and treatments. Electrical bioimpedance spectroscopy (EBIS) methods are non-invasive,inexpensive, and efficient alternatives for the estimation of body fluids. However, these methods areindirect, and their robustness and validity are unclear.Regarding the recording of measurements, a controversy developed regarding a spectrum deviationin the impedance plane, which is caused by capacitive leakage. This deviation is frequentlycompensated for by the extended Cole model, which lacks a theoretical basis; however, there is nomethod published to estimate the parameters. In this thesis, a simplified model to correct thedeviation was proposed and tested. The model consists of an equivalent capacitance in parallel withthe load.Subsequently, two other measurement artefacts were considered. Both artefacts were frequentlydisregarded with regard to total body and segmental EBIS measurements as their influence isinsignificant with suitable skin-electrode contact. However, this case is not always valid, particularlyfrom a textile-enabled measurement system perspective. In the estimation of body fluids, EBIS dataare fitted to a model to obtain resistances at low and high frequencies. These resistances can berelated to body fluid volumes. In order to minimise the influence of all three artefacts on theestimation of body fluids and improve the robustness and suitability of the model fitting the differentdomains of immittance were used and tested. The conductance in a reduced frequency spectrum wasproposed as the most robust domain against the artefacts considered.The robustness and accuracy of the method did not increase, even though resistances at low and highfrequencies can be robustly estimated against measurement artefacts. Thus, there is likely error in therelation between the resistances and volumes. Based on a theoretical analysis, state of the artmethods were reviewed and their limitations were identified. New methods were also proposed. Allmethods were tested using a clinical database of patients involved in growth hormone replacementtherapy. The results indicated EBIS are accurate methods to estimate body fluids, however they haverobustness limits. It is hypothesized that those limits in extra-cellular fluid are primarily due toanisotropy, in total body fluid they are primarily due to the uncertainty ρi, and errors in intra-cellularfluid are primarily due to the addition of errors in extracellular and total body fluid. Currently, theseerrors cannot be prevented or minimised. Thus, the limitations for robustness must be predicted priorto applying EBIS to estimate body fluids.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2013. 83 p.
Series
Trita-STH : report, ISSN 1653-3836 ; 2013:7
Keyword
Bioimpedance, Cole, Body Fluid
National Category
Medical Engineering
Identifiers
urn:nbn:se:kth:diva-128529 (URN)978-91-7501-874-4 (ISBN)
Public defence
2013-10-04, Sal 3-264, Alfred Nobels allé 10, Fremingsberg, 13:00 (English)
Opponent
Supervisors
Note

QC 20130917

Available from: 2013-09-17 Created: 2013-09-12 Last updated: 2013-09-17Bibliographically approved

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