Estimation of body fluids with bioimpedance spectroscopy: state of the art methods and proposal of novel methods
2015 (English)In: Physiological Measurement, ISSN 0967-3334, E-ISSN 1361-6579, Vol. 36, no 10Article in journal (Refereed) Published
Determination of body fluids is a useful common practice in determination of disease mechanisms and treatments. Bioimpedance spectroscopy (BIS) methods are non-invasive, inexpensive and rapid alternatives to reference methods such as tracer dilution. However, they are indirect and their robustness and validity are unclear. In this article, state of the art methods are reviewed, their drawbacks identified and new methods are proposed. All methods were tested on a clinical database of patients receiving growth hormone replacement therapy. Results indicated that most BIS methods are similarly accurate (e.g. < 0.5 +/- 3.0% mean percentage difference for total body water) for estimation of body fluids. A new model for calculation is proposed that performs equally well for all fluid compartments (total body water, extra-and intracellular water). It is suggested that the main source of error in extracellular water estimation is due to anisotropy, in total body water estimation to the uncertainty associated with intracellular resistivity and in determination of intracellular water a combination of both.
Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2015. Vol. 36, no 10
bioimpedance, body composition, body fluids estimation
Medical Laboratory and Measurements Technologies
IdentifiersURN: urn:nbn:se:kth:diva-128807DOI: 10.1088/0967-3334/36/10/2171ISI: 000367690500013ScopusID: 2-s2.0-84947596900OAI: oai:DiVA.org:kth-128807DiVA: diva2:648789
Updated from manuscript to article in journal.
QC 201602012013-09-172013-09-172016-02-01Bibliographically approved