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Structural insights into substrate recognition in proton-dependent oligopeptide transporters
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2013 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 14, no 9, 804-810 p.Article in journal (Refereed) Published
Abstract [en]

Short-chain peptides are transported across membranes through promiscuous proton-dependent oligopeptide transporters (POTs)-a subfamily of the major facilitator superfamily (MFS). The human POTs, PEPT1 and PEPT2, are also involved in the absorption of various drugs in the gut as well as transport to target cells. Here, we present a structure of an oligomeric POT transporter from Shewanella oneidensis (PepT(So2)), which was crystallized in the inward open conformation in complex with the peptidomimetic alafosfalin. All ligand-binding residues are highly conserved and the structural insights presented here are therefore likely to also apply to human POTs.

Place, publisher, year, edition, pages
2013. Vol. 14, no 9, 804-810 p.
Keyword [en]
alafosfalin, major facilitator superfamily, proton-dependent oligopeptide transporter, substrate recognition, x-ray structure
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-129104DOI: 10.1038/embor.2013.107ISI: 000323753100013ScopusID: 2-s2.0-84883489166OAI: diva2:652150
Swedish Research CouncilEU, FP7, Seventh Framework Programme

QC 20130930

Available from: 2013-09-30 Created: 2013-09-19 Last updated: 2013-09-30Bibliographically approved

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Jegerschöld, CarolineZhu, Lin
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