Nanoparticles with aggregation-induced emission for monitoring long time cell membrane interactions
2013 (English)In: Progress In Electromagnetics Research, ISSN 1070-4698, E-ISSN 1559-8985, Vol. 140, 313-325 p.Article in journal (Refereed) Published
We perform the long time monitoring of nanoparticle-cell membrane interaction with high spatial and temporal resolution. The 2, 3-bis(4-(pheny1(4-(1, 2, 2-triphenylvinyl) phenyl)amino)phenyl) fumaronitrile (TPE-TPA-FN) is doped in organically modified silica (ORMOSIL) to be a biocompatible nanoprobe, which displays an aggregation-induced emission (ATE) effect. Photobleaching resistance of this synthesized nanoparticle is tested and compared with its similar counterpart, which proves its superiority and capability of long term fluorescence emission. We utilize the objective-based total internal reflection microscopy combined with the living cell incubation platform to investigate the cell uptake process of this nanoparticle in real time.
Place, publisher, year, edition, pages
2013. Vol. 140, 313-325 p.
Total Internal-Reflection, Microscopy, Fluorescence, Molecules
Electrical Engineering, Electronic Engineering, Information Engineering
IdentifiersURN: urn:nbn:se:kth:diva-129138DOI: 10.2528/PIER13040212ISI: 000323537100018ScopusID: 2-s2.0-84878775171OAI: oai:DiVA.org:kth-129138DiVA: diva2:652333
QC 201309302013-09-302013-09-192013-11-19Bibliographically approved