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Feasibility of Gd Contrast Agent in Spectral Computed Tomography
KTH, School of Engineering Sciences (SCI), Physics.
KTH, School of Engineering Sciences (SCI), Physics.
2013 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

X-ray computed tomography (CT) is currently a vital diagnostic tool in hospitals

the world over. To be able to image a patient's interior quickly can facilitate a

diagnosis so that proper treatment can be administered. In some cases a contrast

agent is administered intravenously prior to the CT-scan, in order to enhance image

quality. Most contrast agents are heavy-element based and have a sudden increase

in attenuation at the k-edge due to photoelectric absorption of the photons.

New technology utilizing multi-bin spectral CT is under development. This tech-

nology opens up for the possibility to isolate the image contribution of this sudden

increase in attenuation at the the k-edge.

This report investigates the feasibility of using gadolinium-based contrast agents

(GBCA) in multi-bin spectral CT. With a high k-edge, gadolinium is well suited

for k-edge imaging. However, GBCA are currently only endorsed for magnetic res-

onance imaging (MRI), raising the question if currently used concentrations are

su-cient for CT practice.

We model two cross-sections containing targets of various areas and determine the

detectability of said targets for concentrations currently endorsed in MRI. Higher

concentrations are considered when motivated.

We conclude that detection of lesions and haemorrhaging in soft tissue, as well

as cerebral haemorrhaging, is possible with the concentrations currently exercised

in MRI. Additionally, we conclude that to detect residual blood  ow in the case of

ischemia caused by thrombosis, higher concentrations must be considered.

These results clearly indicate that currently endorsed concentrations of GBCA, in

combination with k-edge imaging, could provide su-cient contrast in CT-practice.

Place, publisher, year, edition, pages
2013. , 14 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-129516OAI: oai:DiVA.org:kth-129516DiVA: diva2:652623
Supervisors
Available from: 2013-10-01 Created: 2013-10-01 Last updated: 2013-10-01Bibliographically approved

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