Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Biocompatibility of OSTE polymers studied by cell growth experiments
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-9651-4900
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics.ORCID iD: 0000-0003-3402-9672
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-9177-1174
Show others and affiliations
2013 (English)In: Proceedings of the 17th Int. Conf. on Miniaturized Systems for Chemistry  and Life Sciences (microTAS), Freiburg, Germany, 2013Conference paper, Published paper (Refereed)
Abstract [en]

The recently introduced OSTE polymer technology has shown very useful features for microfluidics for lab-on-a-chip applications. However, no data has yet been published on cell viability on OSTE. In this work, we study the biocompatibility of three OSTE formulations by cell growth experiments. Moreover, we investigate the effect of varying thiol excess on cell viability on OSTE surfaces. The results show poor cell viability on one OSTE formulation, and viability comparable with polystyrene on a second formulation with thiol excess below 60%. In the third formulation, we observe cell proliferation. These results are promising for cell-based assays in OSTE microfluidic devices.

Place, publisher, year, edition, pages
Freiburg, Germany, 2013.
Keyword [en]
loc OSTE lab-on-chip biocompatibility
National Category
Medical Materials
Identifiers
URN: urn:nbn:se:kth:diva-129546Scopus ID: 2-s2.0-84907370206OAI: oai:DiVA.org:kth-129546DiVA: diva2:652888
Conference
The 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013), Freiburg, 27-31 October 2013
Projects
CellRing
Funder
Swedish Research Council, B0460801EU, European Research Council, 267528
Note

QC 20131122

Available from: 2013-10-02 Created: 2013-10-02 Last updated: 2017-10-02Bibliographically approved
In thesis
1. Thiol-ene and Thiol-ene-epoxy Based Polymers for Biomedical Microdevices
Open this publication in new window or tab >>Thiol-ene and Thiol-ene-epoxy Based Polymers for Biomedical Microdevices
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Within healthcare there is a market pull for biomedical devices that can rapidly perform laboratory processes, such as diagnostic testing, in a hand-held format. For this reason, biomedical devices must become smaller, more sophisticated, and easier to use for a reasonable cost. However, despite the accelerating academic research on biomedical microdevices, and especially plastic-based microfluidic chips, there is still a gap between the inventions in academia and their benefit to society. To bridge this gap there is a need for new materials which both exhibit similar properties as industrial thermoplastics, and that enable rapid prototyping in academia.

In this thesis, thiol-ene and thiol-ene-epoxy thermosets are evaluated both in terms of their suitability for rapid prototyping of biomedical microdevices and their potential for industrial manufacturing of “lab-on-chips”.

The first part of the thesis focuses on material development of thiol-ene and thiol-ene-epoxy thermosets. Chemical and mechanical properties are studied, as well as in vitro biocompatibility with cells.

The second part of the thesis focuses on microfabrication methods for both thermosets. This includes reaction injection molding, photostructuring, and surface modification. It is demonstrated how thiol-ene and thiol-ene-epoxy both provide advantageous thermo-mechanical properties and versatile surface modifications via “thiol-click chemistry”.

In the end of the thesis, two applications for both polymer platforms are demonstrated. Firstly, thiol-ene is used for constructing nanoliter well arrays for liquid storage and on-demand electrochemical release. Secondly, thiol-ene-epoxy is used to enhance the biocompatibility of neural probes by tuning their flexibility.

It is concluded that both thiol-ene and thiol-ene-epoxy thermosets exhibit several properties that are highly suitable for rapid prototyping as well as for scalable manufacturing of biomedical microdevices.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2017. 93 p.
Series
TRITA-EE, ISSN 1653-5146 ; 2017:129
Keyword
biomedical microdevices, lab-on-a-chip, off-stoichiometry thiol-ene, OSTE, thiol-ene-epoxy, hybrid polymer networks, reaction injection molding, photostructuring, surface modification, bonding, liquid encapsulation, biocompatibility
National Category
Electrical Engineering, Electronic Engineering, Information Engineering Medical Engineering Medical Biotechnology Materials Engineering
Research subject
Electrical Engineering
Identifiers
urn:nbn:se:kth:diva-215110 (URN)978-91-7729-530-3 (ISBN)
Public defence
2017-11-13, F3, Lindstedtsvägen 26, Stockholm, 10:15 (English)
Opponent
Supervisors
Funder
EU, European Research CouncilEU, FP7, Seventh Framework Programme
Note

QC 20171003

Available from: 2017-10-03 Created: 2017-10-02 Last updated: 2017-10-03Bibliographically approved

Open Access in DiVA

fulltext(241 kB)175 downloads
File information
File name FULLTEXT01.pdfFile size 241 kBChecksum SHA-512
389993de519691259cba3644cae8b324c0191527f28ddf1ba61ffe7c561851589ae961ca9a9f44179befa255eebdaac6f429dacaa3d0d0098e333a4db563fab4
Type fulltextMimetype application/pdf

Other links

ScopusmicroTAS2013

Authority records BETA

Vastesson, AlexanderZelenina, MarinaPardon, GaspardWijngaart, Wouter van derHaraldsson, TommyBrismar, HjalmarGylfason, Kristinn B.

Search in DiVA

By author/editor
Errando-Herranz, CarlosVastesson, AlexanderZelenina, MarinaPardon, GaspardWijngaart, Wouter van derHaraldsson, TommyBrismar, HjalmarGylfason, Kristinn B.
By organisation
Micro and NanosystemsCell Physics
Medical Materials

Search outside of DiVA

GoogleGoogle Scholar
Total: 175 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 665 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf