Visualization of multimodal polymer-shelled contrast agents using ultrasound contrast sequences: an experimental study in a tissue mimicking flow phantom
2013 (English)In: Cardiovascular Ultrasound, ISSN 1476-7120, Vol. 11, 33- p.Article in journal (Refereed) Published
Background: A multimodal polymer-shelled contrast agent (CA) with target specific potential was recently developed and tested for its acoustic properties in a single element transducer setup. Since the developed polymeric CA has different chemical composition than the commercially available CAs, there is an interest to study its acoustic response when using clinical ultrasound systems. The aim of this study was therefore to investigate the acoustic response by studying the visualization capability and shadowing effect of three polymer-shelled CAs when using optimized sequences for contrast imaging. Methods: The acoustic response of three types of the multimodal CA was evaluated in a tissue mimicking flow phantom setup by measuring contrast to tissue ratio (CTR) and acoustic shadowing using five image sequences optimized for contrast imaging. The measurements were performed over a mechanical index (MI) range of 0.2-1.2 at three CA concentrations (10(6), 10(5), 10(4) microbubbles/ml). Results: The CTR-values were found to vary with the applied contrast sequence, MI and CA. The highest CTR-values were obtained when a contrast sequence optimized for higher MI imaging was used. At a CA concentration of 106 microbubbles/ml, acoustic shadowing was observed for all contrast sequences and CAs. Conclusions: The CAs showed the potential to enhance ultrasound images generated by available contrast sequences. A CA concentration of 106 MBs/ml implies a non-linear relation between MB concentration and image intensity.
Place, publisher, year, edition, pages
2013. Vol. 11, 33- p.
Acoustic shadowing, Contrast agent, Contrast sequences, Contrast to tissue ratio, Flow phantom, Multimodal
Cardiac and Cardiovascular Systems
IdentifiersURN: urn:nbn:se:kth:diva-129627DOI: 10.1186/1476-7120-11-33ISI: 000324140500001ScopusID: 2-s2.0-84883074083OAI: oai:DiVA.org:kth-129627DiVA: diva2:653220
FunderEU, FP7, Seventh Framework Programme, 245572
QC 201310032013-10-032013-10-032015-04-01Bibliographically approved