Interactome and Pathway Analysis of EBNA Transformed Human B-Cell.
Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Epstein-barr virus (EBV) is a member of human herpesvirus family which infects most human populations without obvious symptom, that is, latent infection. EBV establishes the latent infection through protein interactions between human and viral encoded proteins.
EBV encoded nuclear antigens (EBNA) are important viral gene products which are essential for maintaining EBV infection phenotype, such as proliferation and anti-apoptosis. Through interacting with EBNA binding proteins in host cell, EBNAs modulate both viral and cellular transcription.
In this project, I started from identified EBNA binding proteins and performed interactome and pathway analysis. A global map of pathways regulated by EBNAs is reconstructed. In addition, a simplified qualitative model is implemented. Results show that most EBNAs (except EBNA-6) have anti-apoptosis effects and that the Wnt pathway is essential for cell proliferation.
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Place, publisher, year, edition, pages
Trita-CSC-E, ISSN 1653-5715 ; 2011:113
IdentifiersURN: urn:nbn:se:kth:diva-130745OAI: oai:DiVA.org:kth-130745DiVA: diva2:654192
Master of Science - Computational and Systems Biology