Change search
ReferencesLink to record
Permanent link

Direct link
Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters
Show others and affiliations
2013 (English)In: Journal of Psychiatric Research, ISSN 0022-3956, E-ISSN 1879-1379, Vol. 47, no 11, 1572-1580 p.Article in journal (Refereed) Published
Abstract [en]

Psychiatric disorders are caused by perturbed molecular pathways that affect brain circuitries. The identification of specific biosignatures that are the result of altered pathway activities in major depression, bipolar disorder and schizophrenia can contribute to a better understanding of disease etiology and aid in the implementation of diagnostic assays. In the present study we identified disease-specific protein biosignatures in cerebrospinal fluid of depressed (n: 36), bipolar (n: 27) and schizophrenic (n: 35) patients using the Reverse Phase Protein Microarray technology. These biosignatures were able to stratify patient groups in an objective manner according to cerebrospinal fluid protein expression patterns. Correct classification rates were over 90%. At the same time several protein sets that play a role in neuronal growth, proliferation and differentiation (NEGR1, NPDC1), neurotransmission (SEZ6) and protection from oxidative damage (GPX3) were able to distinguish diseased from healthy individuals (n: 35) indicating a molecular signature overlap for the different psychiatric phenotypes. Our study is a first step toward implementing a psychiatric patient stratification system based on molecular biosignatures. Protein signatures may eventually be of use as specific and sensitive biomarkers in clinical trials not only for patient diagnostic and subgroup stratification but also to follow treatment response.

Place, publisher, year, edition, pages
2013. Vol. 47, no 11, 1572-1580 p.
Keyword [en]
Psychiatric patient group stratification, Biosignatures, Multiplex analysis, Cerebrospinal fluid, Protein levels, Protein clusters
National Category
URN: urn:nbn:se:kth:diva-133968DOI: 10.1016/j.jpsychires.2013.07.021ISI: 000325841600004ScopusID: 2-s2.0-84884412202OAI: diva2:664415

QC 20131115

Available from: 2013-11-15 Created: 2013-11-14 Last updated: 2013-11-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Uhlén, Mathias
By organisation
Proteomics and Nanobiotechnology
In the same journal
Journal of Psychiatric Research

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 15 hits
ReferencesLink to record
Permanent link

Direct link