Review: The role of biomechanical modeling in the rupture risk assessment for abdominal aortic aneurysms
2013 (English)In: Journal of Biomechanical Engineering, ISSN 0148-0731, Vol. 135, no 2, 021010- p.Article, review/survey (Refereed) Published
AAA disease is a serious condition and a multidisciplinary approach including biomechanics is needed to better understand and more effectively treat this disease. A rupture risk assessment is central to the management of AAA patients, and biomechanical simulation is a powerful tool to assist clinical decisions. Central to such a simulation approach is a need for robust and physiologically relevant models. Vascular tissue senses and responds actively to changes in its mechanical environment, a crucial tissue property that might also improve the biomechanical AAA rupture risk assessment. Specifically, constitutive modeling should not only focus on the (passive) interaction of structural components within the vascular wall, but also how cells dynamically maintain such a structure. In this article, after specifying the objectives of an AAA rupture risk assessment, the histology and mechanical properties of AAA tissue, with emphasis on the wall, are reviewed. Then a histomechanical constitutive description of the AAA wall is introduced that specifically accounts for collagen turnover. A test case simulation clearly emphasizes the need for constitutive descriptions that remodels with respect to the mechanical loading state. Finally, remarks regarding modeling of realistic clinical problems and possible future trends conclude the article.
Place, publisher, year, edition, pages
2013. Vol. 135, no 2, 021010- p.
Abdominal aortic aneurysms, Biomechanical modeling, Biomechanical simulation, Clinical decision, Clinical problems, Mechanical environment, Mechanical loading, Multi-disciplinary approach, Possible futures, Rupture risk, Simulation approach, Structural component, Test case, Tissue properties, Vascular tissue, Vascular wall, Computer simulation, Mechanical properties, Physiological models, Risk assessment, Tissue, Biomechanics, collagen, abdominal aorta aneurysm, aorta wall, arterial wall thickness, family history, gender, histology, human, hypertension, metabolism, review, thrombus, aorta rupture, biological model, pathology, pathophysiology, Aortic Aneurysm, Abdominal, Aortic Rupture, Humans, Models, Biological
IdentifiersURN: urn:nbn:se:kth:diva-134689DOI: 10.1115/1.4023254ISI: 000326075300011ScopusID: 2-s2.0-8487361737OAI: oai:DiVA.org:kth-134689DiVA: diva2:667610
FunderVinnovaSwedish Research Council, 2006-7568EU, FP7, Seventh Framework Programme, FAD-200647
QC 201311272013-11-272013-11-272013-11-29Bibliographically approved