A comparative study of dissociation of thymidine molecules following valence or core photoionization
2013 (English)In: Journal of Physics B: Atomic, Molecular and Optical Physics, ISSN 0953-4075, E-ISSN 1361-6455, Vol. 46, no 21, 215102- p.Article in journal (Refereed) Published
We have studied the fragmentation of gas phase thymidine following valence and core ionization using synchrotron radiation, combined with electron energy and ion mass resolved detection in coincidence. To identify certain fragment masses C-13 labelled thymidine was also used. We find that in large part, the photofragmentation of thymidine can be described as separated thymine and 2-deoxy-D-ribose cations. However, also the intact thymidine radical cation, formation of intact base and sugar cations from glycosidic bond cleavage and several new thymidine-specific fragments are observed after valence ionization. Conversely, at the photoionization of C 1s electrons neither parent thymidine cations nor any fragments above 55 amu were detected, and only ion pairs with small masses survive core ionization, Auger decay and the subsequent Coulomb separation of the DNA sub-unit. This demonstrates the genotoxic nature of soft x-rays which in cells induce complex clustered damage similar to those yielded by heavy particles.
Place, publisher, year, edition, pages
2013. Vol. 46, no 21, 215102- p.
Electron-Impact, Gas-Phase, 2-Deoxy-D-Ribose Molecules, Coincidence Technique, Triple Coincidence, Condensed-Phase, Fragmentation, Ionization, Uracil, Photofragmentation
Other Physics Topics
IdentifiersURN: urn:nbn:se:kth:diva-134721DOI: 10.1088/0953-4075/46/21/215102ISI: 000326434400006ScopusID: 2-s2.0-84888367134OAI: oai:DiVA.org:kth-134721DiVA: diva2:668314
FunderSwedish Research Council
QC 201311292013-11-292013-11-282013-11-29Bibliographically approved