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A comparative study of dissociation of thymidine molecules following valence or core photoionization
KTH, School of Engineering Sciences (SCI), Physics, Atomic and Molecular Physics.ORCID iD: 0000-0001-7389-5501
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2013 (English)In: Journal of Physics B: Atomic, Molecular and Optical Physics, ISSN 0953-4075, E-ISSN 1361-6455, Vol. 46, no 21, 215102- p.Article in journal (Refereed) Published
Abstract [en]

We have studied the fragmentation of gas phase thymidine following valence and core ionization using synchrotron radiation, combined with electron energy and ion mass resolved detection in coincidence. To identify certain fragment masses C-13 labelled thymidine was also used. We find that in large part, the photofragmentation of thymidine can be described as separated thymine and 2-deoxy-D-ribose cations. However, also the intact thymidine radical cation, formation of intact base and sugar cations from glycosidic bond cleavage and several new thymidine-specific fragments are observed after valence ionization. Conversely, at the photoionization of C 1s electrons neither parent thymidine cations nor any fragments above 55 amu were detected, and only ion pairs with small masses survive core ionization, Auger decay and the subsequent Coulomb separation of the DNA sub-unit. This demonstrates the genotoxic nature of soft x-rays which in cells induce complex clustered damage similar to those yielded by heavy particles.

Place, publisher, year, edition, pages
2013. Vol. 46, no 21, 215102- p.
Keyword [en]
Electron-Impact, Gas-Phase, 2-Deoxy-D-Ribose Molecules, Coincidence Technique, Triple Coincidence, Condensed-Phase, Fragmentation, Ionization, Uracil, Photofragmentation
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URN: urn:nbn:se:kth:diva-134721DOI: 10.1088/0953-4075/46/21/215102ISI: 000326434400006Scopus ID: 2-s2.0-84888367134OAI: oai:DiVA.org:kth-134721DiVA: diva2:668314
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Swedish Research Council
Note

QC 20131129

Available from: 2013-11-29 Created: 2013-11-28 Last updated: 2017-12-06Bibliographically approved

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Rachlew, Elisabeth

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