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Comparative analysis of toxicological evaluations for dermal exposure performed under two different EU regulatory frameworks
KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.
KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.ORCID iD: 0000-0003-3799-4814
2014 (English)In: Regulatory toxicology and pharmacology, ISSN 0273-2300, E-ISSN 1096-0295, Vol. 68, no 1, 51-58 p.Article in journal (Refereed) Published
Abstract [en]

Dermal exposure to chemicals is highly relevant in relation to the use of cosmetic products, both in consumers and in individuals exposed occupationally. Regulatory frameworks exist within the EU to limit the dermal exposure of the general population and workers to chemicals in general, as well as to limit the use of certain substances in cosmetic products. The objective of the study was to investigate and compare toxicological evaluations of dermal exposure performed under current regulatory frameworks. The publicly disseminated hazard information under the respective regulatory frameworks was compiled and compared for the five substances resorcinol, p-phenylenediamine, p-aminophenol, N-phenyl-p-phenylenediamine, and diethylene glycol monoethyl ether. A low consistency between evaluations was observed in respect to data coverage and cited dose descriptors. No systematic differences over all five substances were identified from the viewpoint of dermal hazard assessment. The critical effect and corresponding systemic effect dose descriptor was identical for two substances, differed somewhat for two other (a factor of 2-2.5). For N-phenyl-p-phenylenediamine a critical effect was only identified under REACH.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 68, no 1, 51-58 p.
Keyword [en]
Regulation, Derived no effect levels, Risk management, Cosmetics regulation, REACH
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:kth:diva-136184DOI: 10.1016/j.yrtph.2013.11.006ISI: 000330601500006Scopus ID: 2-s2.0-84889663997OAI: oai:DiVA.org:kth-136184DiVA: diva2:675556
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare
Note

QC 20140310

Available from: 2013-12-04 Created: 2013-12-04 Last updated: 2017-12-06Bibliographically approved

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Westerholm & Schenk 2014(288 kB)173 downloads
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Schenk, Linda

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