Change search
ReferencesLink to record
Permanent link

Direct link
Comparative analysis of toxicological evaluations for dermal exposure performed under two different EU regulatory frameworks
KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.
KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.ORCID iD: 0000-0003-3799-4814
2014 (English)In: Regulatory toxicology and pharmacology, ISSN 0273-2300, E-ISSN 1096-0295, Vol. 68, no 1, 51-58 p.Article in journal (Refereed) Published
Abstract [en]

Dermal exposure to chemicals is highly relevant in relation to the use of cosmetic products, both in consumers and in individuals exposed occupationally. Regulatory frameworks exist within the EU to limit the dermal exposure of the general population and workers to chemicals in general, as well as to limit the use of certain substances in cosmetic products. The objective of the study was to investigate and compare toxicological evaluations of dermal exposure performed under current regulatory frameworks. The publicly disseminated hazard information under the respective regulatory frameworks was compiled and compared for the five substances resorcinol, p-phenylenediamine, p-aminophenol, N-phenyl-p-phenylenediamine, and diethylene glycol monoethyl ether. A low consistency between evaluations was observed in respect to data coverage and cited dose descriptors. No systematic differences over all five substances were identified from the viewpoint of dermal hazard assessment. The critical effect and corresponding systemic effect dose descriptor was identical for two substances, differed somewhat for two other (a factor of 2-2.5). For N-phenyl-p-phenylenediamine a critical effect was only identified under REACH.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 68, no 1, 51-58 p.
Keyword [en]
Regulation, Derived no effect levels, Risk management, Cosmetics regulation, REACH
National Category
Environmental Health and Occupational Health
URN: urn:nbn:se:kth:diva-136184DOI: 10.1016/j.yrtph.2013.11.006ISI: 000330601500006ScopusID: 2-s2.0-84889663997OAI: diva2:675556
Forte, Swedish Research Council for Health, Working Life and Welfare

QC 20140310

Available from: 2013-12-04 Created: 2013-12-04 Last updated: 2014-07-02Bibliographically approved

Open Access in DiVA

Westerholm & Schenk 2014(288 kB)132 downloads
File information
File name FULLTEXT01.pdfFile size 288 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textScopusSciencedirect

Search in DiVA

By author/editor
Westerholm, EmmaSchenk, Linda
By organisation
In the same journal
Regulatory toxicology and pharmacology
Environmental Health and Occupational Health

Search outside of DiVA

GoogleGoogle Scholar
Total: 132 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 38 hits
ReferencesLink to record
Permanent link

Direct link